The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

J Vogel; S H Hinrichs; R K Reynolds; P A Luciw; G Jay

doi:10.1038/335606a0

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

Nature. 1988 Oct 13;335(6191):606-11. doi: 10.1038/335606a0.

Authors

J Vogel¹, S H Hinrichs, R K Reynolds, P A Luciw, G Jay

Affiliation

¹ Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20892.

PMID: 2845275
DOI: 10.1038/335606a0

Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Base Sequence
Cell Division
Gene Products, tat
HIV / genetics*
Male
Mice
Mice, Transgenic
Molecular Sequence Data
RNA, Messenger / metabolism
Sarcoma, Kaposi / genetics*
Sarcoma, Kaposi / pathology
Skin / metabolism
Skin / pathology
Skin Neoplasms / genetics
Skin Neoplasms / pathology
Transcription Factors / metabolism
tat Gene Products, Human Immunodeficiency Virus

Substances

Gene Products, tat
RNA, Messenger
Transcription Factors
tat Gene Products, Human Immunodeficiency Virus