Abstract
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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Cloning, Molecular
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DNA / genetics
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Escherichia coli / genetics
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Gene Expression Regulation
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Glycoproteins / genetics*
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Glycoproteins / therapeutic use
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Humans
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Lymphokines / genetics
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Lymphotoxin-alpha / genetics
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Mice
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Protein Precursors / genetics
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Sarcoma, Experimental / therapy
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Tumor Necrosis Factor-alpha
Substances
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Glycoproteins
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Lymphokines
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Lymphotoxin-alpha
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Protein Precursors
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Tumor Necrosis Factor-alpha
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DNA
Associated data
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GENBANK/X01394
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GENBANK/X02159
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GENBANK/X02910