Myxomas of the mandible and maxillary sinus are rare but well described neoplasms. They appear to be odontogenic in origin related to malformations or missing teeth. Their local aggressiveness and ability to erode bone should not be underestimated. Based on our experience we feel that conservative surgical management including total excision and sparing of uninvolved structures allows for preservation of function. Long-term follow-up is necessary and in case of recurrence, a more radical procedure may have to be performed for this benign disease.