Abstract
Cardiovascular beriberi is a syndrome caused by thiamine deficiency and characterized by systemic vasodilatation, heart failure and lactic acidosis. The occurrence of heart failure and vasodilatation is yet unexplained: neither theoretical nor experimental data are known. In this article, it is suggested that a fall of cellular ATP levels causes heart failure and that the release of adenosine is the cause of vasodilatation.
MeSH terms
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Acetyl Coenzyme A / metabolism*
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Acidosis, Lactic / etiology
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Acidosis, Lactic / metabolism
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Adenosine / metabolism*
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Adenosine Triphosphate / metabolism*
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Beriberi / complications*
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Beriberi / metabolism
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Ethanol / pharmacology
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Heart Failure / etiology*
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Heart Failure / metabolism
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Humans
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Ketoglutarate Dehydrogenase Complex / deficiency
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Ketoglutarate Dehydrogenase Complex / physiology*
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Models, Biological
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Pyruvate Dehydrogenase Complex Deficiency Disease / etiology*
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Pyruvate Dehydrogenase Complex Deficiency Disease / metabolism
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Thiamine / physiology*
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Vasodilation / physiology*
Substances
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Ethanol
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Acetyl Coenzyme A
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Adenosine Triphosphate
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Ketoglutarate Dehydrogenase Complex
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Adenosine
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Thiamine