Background Mild perioperative hypothermia, which is common during major surgery, may
promote surgical-wound infection by triggering thermoregulatory vasoconstriction, which …

Background Destruction by oxidation, or oxidative killing, is the most important defense against
surgical pathogens and depends on the partial pressure of oxygen in contaminated tissue…

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to
phospholipids 1 , 2 . To date, ferroptosis has been thought to be controlled only by the …

Background: Intraoperative hypotension may contribute to postoperative acute kidney injury
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …

Background How best to characterize intraoperative hypotension remains unclear. Thus, the
authors assessed the relationship between myocardial and kidney injury and intraoperative …

Opioid treatment for postoperative or chronic pain is frequently associated with adverse effects,
the most common being dose-limiting and debilitating bowel dysfunction. Postoperative …

Background Intraoperative hypothermia is common and persists for several hours after
surgery. Hypothermia may prolong immediate recovery by augmenting anesthetic potency, …

Background Core hypothermia after induction of general anesthesia results from an internal
core-to-peripheral redistribution of body heat and a net loss of heat to the environment. …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …