Man is the only eukaryotic organism in which it has been reported that the circadian system
cannot be entrained to a 24‐h period by a simple light‐dark (LD) cycle. In this paper, we …

THE study of circadian (approximately 24-hour) rhythms has within the past decade evolved
from a biologic curiosity to a science with enormous implications for clinical medicine. The …

The circadian pacemakers, which time the approximately 24-hour rhythms in sleep and
wakefulness, neuroendocrine, thermoregulatory, and other body functions, resynchronize only …

Human circadian rhythms were once thought to be insensitive to light, with synchronization
to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. …

Excessive daytime sleepiness is a complaint characterizing many disorders of the
wakefulness-sleep cycle. This paper addresses the complaint of sleepiness objectively by an attempt …

Many elderly people complain of disturbed sleep patterns but there is no evidence that the
need to sleep decreases with age; it seems rather that the timing and consolidation of sleep …

We report here the development of a brief drug-free rescheduling treatment (“chronotherapy”)
for Delayed Sleep Phase (DSP) insomnia, a syndrome characterized by sleep-onset …

The "long nights" protocol was designed to evaluate sleep processes and circadian rhythm
parameters in young humans. A total of 19 children (10 boys, ages 11.2 to 14.1 years [mean …

METHODS Subjects Subjects were 10 (five women, five men) elderly volunteers, ages 60-83
years (mean= 70), and 8 (four women, four men) young adults, ages 19-23 years (mean= …

Sedation is the principal side effect of firstgeneration H1 antihistamines, and recent studies
have suggested that this side effect should limit the clinical application of these drugs. The …