Background The limited availability of donor organs has led to a search for alternatives to
liver transplantation to restore liver function and bridge patients to transplantation. We have …

Hepatocellular carcinoma (HCC) is a heterogeneous disease in which tumor subtypes can
be identified based on the presence of adult liver progenitor cells. Having previously …

We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target
of rapamycin (mTOR) complex 1, markedly inhibits the growth of focal lesions in the resistant …

Background: Hepatic oval cells proliferate to replace hepatocytes and restore liver function
when hepatocyte proliferation is compromised or inadequate. Exposure to chemical …

Obesity during childhood and beyond may have its origins during fetal or early postnatal life.
At present, there are no suitable in vivo experimental models to study factors that modulate …

Hepatocyte transplantation has the potential to be an effective therapy for acute liver
disease and metabolic disorders. Our laboratory has focused on late gestation (E19) liver …

Hepatocellular carcinoma is a heterogeneous disease with distinct tumor sub-types based
on expression of markers for hepatocytes and adult liver progenitor cells, also known as oval …

Given that current treatment options for hepatocellular carcinoma (HCC) are of limited
efficacy, we have focused on chemoprevention and the mechanistic Target Of Rapamycin (mTOR)…

Hepatocyte transplantation has the potential to be an effective therapy for liver failure. However,
the application of this therapy has been hampered by identification of an appropriate cell …

We have shown previously that rapamycin, the canonical inhibitor of the mechanistic target of
rapamycin (mTOR), markedly inhibits the growth of focal lesions in the resistant hepatocyte …