Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective
responses in adults with glioblastoma, but the feasibility and tolerability of this approach is yet …

The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously
reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To …

Metastatic melanoma is the most aggressive form of skin cancer with a median overall survival
of less than one year. Advancements in our understanding of how melanoma evades the …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts 1 , …

Pancreatoblastomas are unusual malignant neoplasms of the pediatric pancreas that may
also rarely affect adults. The molecular pathogenesis of pancreatoblastomas is unknown. …

Plastic bronchitis is characterized by marked obstruction of the large airways by bronchial
casts. We reviewed our experience and the literature to determine whether mortality rates are …

BACKGROUND Undifferentiated systemic autoinflammatory diseases (USAIDs) present
diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine …

Objective To identify genetic causes of COACH syndrome Background COACH syndrome is
a rare autosomal recessive disorder characterised by Cerebellar vermis hypoplasia, …

Diagnosis of Hirschsprung disease (HSCR) relies on histologic and/or histochemical
staining of sections from suction rectal biopsies. Acetylcholinesterase histochemistry (AChE) …

Given the limited information regarding BK virus-associated nephropathy (BKVN) in pediatric
kidney transplant recipients, we assessed the incidence, risk factors, clinical and virologic …