Smooth muscle regional contribution to vaginal wall function

…, DJ Lawrence, SH Lindsey, L Desrosiers… - Interface …, 2019 - royalsocietypublishing.org
Pelvic organ prolapse is characterized as the descent of the pelvic organs into the vaginal
canal. In the USA, there is a 12% lifetime risk for requiring surgical intervention. Although …

Biaxial mechanical assessment of the murine vaginal wall using extension–inflation testing

…, CK Conway, L Desrosiers… - Journal of …, 2017 - asmedigitalcollection.asme.org
Progress toward understanding the underlying mechanisms of pelvic organ prolapse (POP)
is limited, in part, due to a lack of information on the biomechanical properties and …

The evolution of evaluation and management of urinary or fecal incontinence and pelvic organ prolapse

…, A Garely, N Noor, L Desrosiers… - Current problems …, 2015 - pubmed.ncbi.nlm.nih.gov
… Scott R Steele, Madhulika G Varma, David Prichard, Adil E Bharucha, Sarah A Vogler,
Askin Erdogan, Satish SC Rao, Ann C Lowry, Erin O Lange, Glen M Hall, Joshua IS Bleier …

Effects of elastase digestion on the murine vaginal wall biaxial mechanical response

…, DJ Capone, L Desrosiers… - Journal of …, 2019 - asmedigitalcollection.asme.org
Although the underlying mechanisms of pelvic organ prolapse (POP) remain unknown,
disruption of elastic fiber metabolism within the vaginal wall extracellular matrix (ECM) has been …

[HTML][HTML] Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function

GL Clark-Patterson, S Roy, L Desrosiers, LR Knoepp… - Scientific Reports, 2021 - nature.com
The vagina plays a critical role in supporting the pelvic organs and loss of support leads to
pelvic organ prolapse. It is unknown what microstructural changes influence prolapse …

[HTML][HTML] Pelvic organ prolapse: a review of in vitro testing of pelvic support mechanisms

…, GL Clark-Patterson, KS Miller, L Desrosiers… - Ochsner …, 2020 - ochsnerjournal.org
Background: Pelvic organ prolapse (POP) affects a significant portion of the female population,
impacting quality of life and often requiring intervention. The exact cause of prolapse is …

[HTML][HTML] Comparison of biaxial biomechanical properties of post-menopausal human prolapsed and non-prolapsed uterosacral ligament

…, I Johnson, EW Harville, LR Buckner, L Desrosiers… - Scientific Reports, 2020 - nature.com
Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a
loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP…

Evaluating residual strain throughout the murine female reproductive system

…, GL Clark, D Bivona, BO Ogola, L Desrosiers… - Journal of …, 2019 - Elsevier
Mounting evidence suggests that cells within soft tissues seek to maintain a preferred
biomechanical state. Residual stress is defined as the stress that remains in a tissue when all …

Direct intracellular measurement of deoxygenated hemoglobin S solubility

ME Fabry, L Desrosiers… - Blood, The Journal of the …, 2001 - ashpublications.org
The solubility of deoxygenated hemoglobin S (HbS), which is the concentration of fully
deoxygenated HbS in equilibrium with polymer (C SAT ), is a factor that determines in vivo …

Biaxial biomechanical properties of the nonpregnant murine cervix and uterus

…, HJ Qureshi, VL Morris, EK Danso, L Desrosiers… - Journal of …, 2019 - Elsevier
From a biomechanical perspective, female reproductive health is an understudied area of
research. There is an incomplete understanding of the complex function and interaction …