Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
…, AL Darrow, CK Derian, L de Garavilla… - … of Pharmacology and …, 1999 - ASPET
We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore
the pathophysiological functions of these receptors. In this report, we evaluated mean arterial …
the pathophysiological functions of these receptors. In this report, we evaluated mean arterial …
Agonists of proteinase‐activated receptor 1 induce plasma extravasation by a neurogenic mechanism
L Garavilla, N Vergnolle, SH Young… - British journal of …, 2001 - Wiley Online Library
Thrombin, generated in the circulation during injury, cleaves proteinase‐activated receptor
1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the …
1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the …
Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G
…, A Roy, J Kervinen, L de Garavilla… - The Journal of …, 2017 - journals.aai.org
Human mast cell chymase (HC) and human neutrophil cathepsin G (hCG) show relatively
similar cleavage specificities: they both have chymotryptic activity but can also cleave …
similar cleavage specificities: they both have chymotryptic activity but can also cleave …
[HTML][HTML] A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo
L de Garavilla, MN Greco, N Sukumar, ZW Chen… - Journal of Biological …, 2005 - ASBMB
Certain leukocytes release serine proteases that sustain inflammatory processes and cause
disease conditions, such as asthma and chronic obstructive pulmonary disease. We …
disease conditions, such as asthma and chronic obstructive pulmonary disease. We …
Use of tube condensation as an indicator of endotracheal tube placement
JJ Kelly, CA Eynon, JL Kaplan, L de Garavilla… - Annals of emergency …, 1998 - Elsevier
Study objective: To determine whether condensation on the inner surface of the endotracheal
tube (vapor trail) is a reliable indicator of intratracheal placement. Methods: Twenty-seven …
tube (vapor trail) is a reliable indicator of intratracheal placement. Methods: Twenty-seven …
Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats
…, MR D'Andrea, AL Darrow, L de Garavilla… - … of Pharmacology and …, 2001 - ASPET
Human platelets possess two distinct thrombin-activated receptors, PAR-1 (protease-activated
receptor-1) and PAR-4, whereas human vascular smooth muscle cells possess only PAR-…
receptor-1) and PAR-4, whereas human vascular smooth muscle cells possess only PAR-…
Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney
…, P Andrade-Gordon, L de Garavilla… - American Journal …, 2003 - journals.physiology.org
Recent studies have indicated that urotensin II (UII), a cyclic peptide, is vasoactive and may
be involved in cardiovascular dysfunctions. It remains unknown, however, whether UII plays …
be involved in cardiovascular dysfunctions. It remains unknown, however, whether UII plays …
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone
…, TW Corcoran, L De Garavilla… - Journal of medicinal …, 2003 - ACS Publications
Inhibitors of human mast cell tryptase (EC 3.4.21.59) have therapeutic potential for treating
allergic or inflammatory disorders. We have investigated transition-state mimetics possessing …
allergic or inflammatory disorders. We have investigated transition-state mimetics possessing …
Mer receptor tyrosine kinase signaling participates in platelet function
…, CK Derian, J Yang, L de Garavilla… - … , and vascular biology, 2004 - Am Heart Assoc
Objective— Recently, mice made deficient in growth arrest–specific gene 6 product (Gas6) or
in which Gas6 gene expression was inhibited were shown to have platelet dysfunction and …
in which Gas6 gene expression was inhibited were shown to have platelet dysfunction and …
Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation
BE Maryanoff, L de Garavilla, MN Greco… - American journal of …, 2010 - atsjournals.org
Rationale: Mast cells and neutrophils are key contributors to the pathophysiological
inflammatory processes that underpin asthma and chronic obstructive pulmonary disease, partly …
inflammatory processes that underpin asthma and chronic obstructive pulmonary disease, partly …