Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
MB Breslin, CD Geng, WV Vedeckis - Molecular Endocrinology, 2001 - academic.oup.com
A new human GR gene sequence (hGR 1Ap/e), which is distinct from the previously identified
human GR promoter and coding sequences, has been isolated and characterized. The …
human GR promoter and coding sequences, has been isolated and characterized. The …
[HTML][HTML] Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation
MS Lan, MB Breslin - The FASEB Journal, 2009 - ncbi.nlm.nih.gov
Zinc-finger transcription factors are DNA-binding proteins that are implicated in many diverse
biological functions. INSM1 (formerly IA-1) contains five zinc-finger motifs and functions as …
biological functions. INSM1 (formerly IA-1) contains five zinc-finger motifs and functions as …
[HTML][HTML] The transcription factor encyclopedia
…, G Boulay, SWZ Olechnowicz, MB Breslin… - Genome biology, 2012 - Springer
Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium
of mini review articles on transcription factors (TFs) that is founded on the principles of …
of mini review articles on transcription factors (TFs) that is founded on the principles of …
[HTML][HTML] Differential processing of proenkephalin by prohormone convertases 1 (3) and 2 and furin.
MB Breslin, I Lindberg, S Benjannet, JP Mathis… - Journal of Biological …, 1993 - Elsevier
Recombinant vaccinia virus vectors were used to coexpress mouse prohormone convertase
1 (mPC1), mPC2, or human furin together with human proenkephalin in GH4C1 cells (rat …
1 (mPC1), mPC2, or human furin together with human proenkephalin in GH4C1 cells (rat …
[HTML][HTML] NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system
MB Breslin, M Zhu, MS Lan - Journal of Biological Chemistry, 2003 - ASBMB
IA-1 is a novel zinc finger transcription factor with a restricted tissue distribution in the
embryonic nervous system and tumors of neuroendocrine origin. The 1.7-kilobase 5′-upstream …
embryonic nervous system and tumors of neuroendocrine origin. The 1.7-kilobase 5′-upstream …
Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding …
MB Breslin, M Zhu, AL Notkins… - Nucleic Acids Research, 2002 - academic.oup.com
A novel cDNA, insulinoma-associated antigen-1 (IA-1), containing five zinc-finger DNA-binding
motifs, was isolated from a human insulinoma subtraction library. IA-1 expression is …
motifs, was isolated from a human insulinoma subtraction library. IA-1 expression is …
INSM1 functions as a transcriptional repressor of the neuroD/β2 gene through the recruitment of cyclin D1 and histone deacetylases
WD Liu, HW Wang, M Muguira, MB Breslin… - Biochemical …, 2006 - portlandpress.com
INSM1/IA-1 (insulinoma-associated 1) is a developmentally regulated zinc-finger transcription
factor, exclusively expressed in the foetal pancreas and nervous system, and in tumours of …
factor, exclusively expressed in the foetal pancreas and nervous system, and in tumours of …
[HTML][HTML] Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest
T Zhang, WD Liu, NA Saunee, MB Breslin… - Journal of biological …, 2009 - ASBMB
INSM1 is a zinc finger transcription factor that plays an important role in pancreatic β-cell
development. To further evaluate its role in cell fate determination, we investigated INSM1 …
development. To further evaluate its role in cell fate determination, we investigated INSM1 …
The human glucocorticoid receptor promoter upstream sequences contain binding sites for the ubiquitous transcription factor, Yin Yang 1
MB Breslin, WV Vedeckis - The Journal of steroid biochemistry and …, 1998 - Elsevier
Studies on the human glucocorticoid receptor (GR) promoter were carried out so as to
understand the regulation of GR expression. A −2738 to +19 fragment of the human GR promoter …
understand the regulation of GR expression. A −2738 to +19 fragment of the human GR promoter …
Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer
C Chen, MB Breslin, MS Lan - Cellular signalling, 2018 - Elsevier
Neuroendocrine (NE) lung tumors account for 20% of total lung cancer cases and represent
a subset of aggressive tumors with metastatic potential. High-risk NE lung cancer patients …
a subset of aggressive tumors with metastatic potential. High-risk NE lung cancer patients …