Interferons (IFN) are an assemblage of signaling proteins made and released by various host
cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza …

Background Currently, hormone replacement therapy (HRT) is the only US Food and Drug
Administration-approved treatment for hot flashes, resulting in clinical improvement in 80%-90…

The manufacturer claims that using the Access Fat Conversion Activity Bar increases fat
utilisation, which would have a glycogen-sparing effect and delay the onset of fatigue from …

A palladium-tellurium binary alloy nanomaterial was synthesized by a one-pot reaction of bis(4-methoxyphenyltelluro)methane
[(4-CH 3 OC 6 H 4 Te) 2 CH 2 ](1) and allylpalladium (II)…

KRAS G12C was recently identified to be potentially druggable by allele-specific covalent
targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this …

KRAS gain-of-function mutations occur in approximately 30% of all human cancers. Despite
more than 30 years of KRAS-focused research and development efforts, no targeted therapy …

Activating mutations in KRAS are among the most common tumor driver mutations. Until
recently, KRAS had been considered undruggable with small molecules; the discovery of the …

In recent years, an increasing number of Campylobacter species have been associated with
human gastrointestinal (GI) diseases including gastroenteritis, inflammatory bowel disease, …

The goal of producing concrete that provides longterm durability with regard to properties
such as improved sulfate resistance and reduced susceptibility to alkali-silica reactions (ASR) …

Assessing target occupancy is critical for establishing proof-of-mechanism for novel inhibitors
and to determine whether robust target inhibition can be achieved at tolerated doses. This …