Background Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk
for cancer have been estimated to have an 85 percent risk of breast cancer. Since the …

THE human DNA mismatch repair gene homologue, hMSH2, on chromosome 2p is involved
in hereditary non-polyposis colon cancer (HNPCC) 1,2 . On the basis of linkage data, a …

Consumer vulnerability is a sometimes misunderstood or misused concept that is equated
erroneously with demographic characteristics, stigmatization, consumer protection, unmet …

… Baker, SM et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit
abnormal chromosomesynapsis in meiosis. Ce//82, 309--319 (1995). …

… , Rose, and Leigh 1993), white water rafting (Arnould and Price 1993), use of computer-mediated
environments (Hoffman and Novak 1996), and sports card show participation (Baker …

Autism is a behaviorally defined neurodevelopmental disorder usually diagnosed in early
childhood that is characterized by impairment in reciprocal communication and speech, …

… As these PMS2-related genes have not been found in mice (SM Baker & RM Liskay,
unpublished data), and apparently do not interact with human MLH1 (126), their function, if any, …

Nostalgia has been a popular subject in a recent stream of research, but the research has
not, as of yet, delineated between the different levels of nostalgia and the levels of emotional …

Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in
a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the …

To date, at least four genes involved in DNA mismatch repair (MMR) have been demonstrated
to be altered in the germline of patients with hereditary nonpolyposis colon cancer: hMSH2…