User profiles for Vamsidhar Velcheti
Vamsidhar Velcheti MD FACP FCCPYale University Verified email at yale.edu Cited by 16788 |
[HTML][HTML] Programmed death ligand-1 expression in non-small cell lung cancer
V Velcheti, KA Schalper, DE Carvajal… - Laboratory …, 2014 - Elsevier
Recent strategies targeting the interaction of the programmed cell death ligand-1 (PD-L1, B7-H1,
CD274) with its receptor, PD-1, resulted in promising activity in early phase clinical trials…
CD274) with its receptor, PD-1, resulted in promising activity in early phase clinical trials…
Artificial intelligence in digital pathology—new tools for diagnosis and precision oncology
In the past decade, advances in precision oncology have resulted in an increased demand
for predictive assays that enable the selection and stratification of patients for treatment. The …
for predictive assays that enable the selection and stratification of patients for treatment. The …
Quantitative assessment of the heterogeneity of PD-L1 expression in non–small-cell lung cancer
…, V Pelekanou, J Rehman, V Velcheti… - JAMA …, 2016 - jamanetwork.com
Importance Early-phase trials with monoclonal antibodies targeting PD-1 (programmed cell
death protein 1) and PD-L1 (programmed cell death 1 ligand 1) have demonstrated durable …
death protein 1) and PD-L1 (programmed cell death 1 ligand 1) have demonstrated durable …
[PDF][PDF] CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene transcription.
However, little is known about its impact on genomic instability and cancer immunity. …
However, little is known about its impact on genomic instability and cancer immunity. …
[HTML][HTML] Sotorasib for Lung Cancers with KRAS p.G12C Mutation
…, G Friberg, V Velcheti… - … England Journal of …, 2021 - Mass Medical Soc
Background Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated
advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was …
advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was …
Predicting cancer outcomes with radiomics and artificial intelligence in radiology
The successful use of artificial intelligence (AI) for diagnostic purposes has prompted the
application of AI-based cancer imaging analysis to address other, more complex, clinical needs…
application of AI-based cancer imaging analysis to address other, more complex, clinical needs…
[HTML][HTML] Efficacy of Selpercatinib in RET Fusion–Positive Non–Small-Cell Lung Cancer
…, F De Braud, E Garralda, V Velcheti… - … England Journal of …, 2020 - Mass Medical Soc
Background RET fusions are oncogenic drivers in 1 to 2% of non–small-cell lung cancers (NSCLCs).
In patients with RET fusion–positive NSCLC, the efficacy and safety of selective …
In patients with RET fusion–positive NSCLC, the efficacy and safety of selective …
[HTML][HTML] The current state of the art and future trends in RAS-targeted cancer therapies
SR Punekar, V Velcheti, BG Neel… - Nature reviews Clinical …, 2022 - nature.com
Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered ‘undruggable’ owing to a lack of pharmacologically targetable …
historically been considered ‘undruggable’ owing to a lack of pharmacologically targetable …
In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas
KA Schalper, V Velcheti, D Carvajal, H Wimberly… - Clinical cancer …, 2014 - AACR
Purpose: Blockade of the PD-1/PD-L1 axis emerged as a promising new therapeutic option
for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and …
for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and …
Radiomics and radiogenomics in lung cancer: a review for the clinician
Lung cancer is responsible for a large proportion of cancer-related deaths across the globe,
with delayed detection being perhaps the most significant factor for its high mortality rate. …
with delayed detection being perhaps the most significant factor for its high mortality rate. …