Carcinogens and DNA damage

JL Barnes, M Zubair, K John, MC Poirier… - Biochemical Society …, 2018 - portlandpress.com
Humans are variously and continuously exposed to a wide range of different DNA-damaging
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …

[HTML][HTML] Epidemiology of mesothelioma in the 21st century in Europe and the United States, 40 years after restricted/banned asbestos use

N Alpert, M van Gerwen, E Taioli - Translational lung cancer …, 2020 - ncbi.nlm.nih.gov
Research has established a strong association between asbestos exposure and malignant
mesothelioma, a deadly form of cancer. Since the early 1980's many countries have …

[HTML][HTML] Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo

DW Greening, H Ji, M Chen, BWS Robinson, IM Dick… - Scientific reports, 2016 - nature.com
Malignant mesothelioma (MM) is a highly-aggressive heterogeneous malignancy, typically
diagnosed at advanced stage. An important area of mesothelioma biology and progression …

[HTML][HTML] Mechanisms and functions of chemerin in cancer: potential roles in therapeutic intervention

WJ Shin, BA Zabel, RK Pachynski - Frontiers in immunology, 2018 - frontiersin.org
Chemerin [RARRES2 [retinoic acid receptor responder 2], TIG2 [tazarotene induced gene 2
(TIG2)]] is a multifunctional cytokine initially described in skin cultures upon exposure to the …

[HTML][HTML] MiR-144: a new possible therapeutic target and diagnostic/prognostic tool in cancers

O Kooshkaki, Z Rezaei, M Rahmati, P Vahedi… - International journal of …, 2020 - mdpi.com
MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in
the tissue and plasma of cancer patients when tested in comparison to healthy individuals …

[HTML][HTML] New perspectives on diagnosis and therapy of malignant pleural mesothelioma

M Rossini, P Rizzo, I Bononi, A Clementz… - Frontiers in …, 2018 - frontiersin.org
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an
incidence that varies significantly within and among different countries around the world. It …

[HTML][HTML] PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive …

S Sarkar Bhattacharya, P Thirusangu, L Jin… - Cell Death & …, 2019 - nature.com
The metabolic signatures of cancer cells are often associated with elevated glycolysis.
Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2 …

[HTML][HTML] Multimodality treatment of malignant pleural mesothelioma

L Berzenji, P Van Schil - F1000Research, 2018 - ncbi.nlm.nih.gov
Malignant pleural mesothelioma (MPM) is a rare disease of the pleura and is largely related
to asbestos exposure. Despite recent advancements in technologies and a greater …

[HTML][HTML] Identification of novel autoantibodies for detection of malignant mesothelioma

X Zhang, W Shen, X Dong, J Fan, L Liu, X Gao… - PloS one, 2013 - journals.plos.org
Background The malignant mesothelioma (MM) survival rate has been hampered by the
lack of efficient and accurate early detection methods. The immune system may detect the …

[HTML][HTML] Treatment patterns and outcomes for patients with malignant pleural mesothelioma in England in 2013–2017: A nationwide CAS registry analysis from the IO …

P Baas, MJ Daumont, L Lacoin, JR Penrod, R Carroll… - Lung Cancer, 2021 - Elsevier
Objectives Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer with a
poor prognosis and limited treatment options. This study assessed the characteristics …