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Research ArticleArticles

Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction

Richard Deichmann, Carl Lavie and Samuel Andrews
Ochsner Journal March 2010, 10 (1) 16-21;
Richard Deichmann
*Department of General Internal Medicine, Ochsner Clinic Foundation, New Orleans, LA
MD
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  • For correspondence: rdeichmann@ochsner.org
Carl Lavie
†Department of Cardiovascular Diseases,, Ochsner Clinic Foundation, New Orleans, LA
MD
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Samuel Andrews
‡Department of Internal Medicine, Section of Endocrinology, Ochsner Clinic Foundation, New Orleans, LA
MD
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    Figure 1

    Mitochondrial energy production. (Reproduced with permission from Steve Fowkes, www.ceri.com/mito.htm.)

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    Figure 2

    Role of hydroxyl-methylglutaryl coenzyme A reductase inhibitors on coenzyme Q10 synthesis.

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    Figure 3

    Mitochondrial respiration.24 Qco2, carbon dioxide production; Qo2, oxygen utilization; V̇o2, oxygen uptake; V̇co2, carbon dioxide output.

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Ochsner Journal
Vol. 10, Issue 1
Mar 2010
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Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction
Richard Deichmann, Carl Lavie, Samuel Andrews
Ochsner Journal Mar 2010, 10 (1) 16-21;

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Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction
Richard Deichmann, Carl Lavie, Samuel Andrews
Ochsner Journal Mar 2010, 10 (1) 16-21;
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  • Article
    • Abstract
    • INTRODUCTION
    • DEFICIENCY STATES OF COENZYME Q10
    • EFFECTS OF COENZYME Q10 SUPPLEMENTATION
    • MEASUREMENTS OF MITOCHONDRIAL FUNCTION
    • THE ELDERLY POPULATION
    • SUMMARY
    • REFERENCES
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Cited By...

  • The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: a systematic review
  • Overcoming Challenges With Statin Therapy
  • The Interaction Between Statins and Exercise: Mechanisms and Strategies to Counter the Musculoskeletal Side Effects of This Combination Therapy
  • Innate and Adaptive Inflammation as a Therapeutic Target in Vascular Disease: The Emerging Role of Statins
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Keywords

  • Coenzyme Q10
  • mitochondrial dysfunction
  • myopathy
  • statins

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