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Letters to the EditorDistance Learning for Educating Anesthesiology ResidentsEditors' ReplyThe β-Blockers Crumbling Continues? A Critical Analysis of the REACH RegistryReply: Beta Blockers May Be Alive, But on Life Support

Alaa A. Abd-Elsayed, Leonardo Seoane, Alberto Morales Salinas, Carl J. Lavie, John P. Lawrence, Ron Amedee, Antonio Coca, James D. DiNicolantonio and James H. O'Keefe
Ochsner Journal March 2013, 13 (1) 166-168;
Alaa A. Abd-Elsayed
Department of Anesthesiology, University of CincinnatiCincinnati, OH
MD, MPH
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Leonardo Seoane
Guest Editors of The Ochsner Journal, Vol. 12, Issue 4Ochsner Clinic FoundationNew Orleans, LA
MD
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  • For correspondence: lseoane{at}ochsner.org ramedee{at}ochsner.org
Alberto Morales Salinas
Cardiocentro “Ernesto Che Guevara”Villa Clara, Cuba
MD, MPH
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  • For correspondence: cardioams{at}yahoo.es
Carl J. Lavie
The University of Queensland School of Medicine, Ochsner Clinical SchoolNew Orleans, LA, Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA
MD
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John P. Lawrence
Department of Anesthesiology, University of CincinnatiCincinnati, OH
MD, MEd
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Ron Amedee
Guest Editors of The Ochsner Journal, Vol. 12, Issue 4Ochsner Clinic FoundationNew Orleans, LA
MD
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  • For correspondence: lseoane{at}ochsner.org ramedee{at}ochsner.org
Antonio Coca
Hypertension and Vascular Risk UnitInstitute of Medicine, Hospital Clinic (IDIBAPS)University of BarcelonaBarcelona, Spain
MD, PhD
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  • For correspondence: acoca{at}clinic.ub.es
James D. DiNicolantonio
Wegman's PharmacyIthaca, NY
PharmD
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James H. O'Keefe
Mid America Heart Institute at St. Luke's Hospital, University of Missouri, Kansas City, MO
MD
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Distance Learning for Educating Anesthesiology Residents

To the Editor:

We read with interest the winter issue of The Ochsner Journal (Volume 12, Number 4) that discussed variable aspects about medical education and mentorship. The issue presented multiple interesting topics, ideas, and some surprising outcomes. Overall it was a great issue that highlighted some educational best practices.

In this letter we want to share another aspect of education that we currently practice at the anesthesiology department at the University of Cincinnati. We have introduced distance learning strategies into the education approach in teaching our residents. Distance learning is a relatively new teaching method that first started in the 1950s. Initially it did not gain much popularity and was dismissed as merely “correspondence courses” or a “cheap and trashy” form of education, but now distance learning has become an emerging and effective educational strategy that is gaining widespread acceptance.1

Our program maintains a series of didactic lectures on Tuesday afternoons from 4:00-6:00 pm and Wednesday mornings from 7:00-8:00 am. In an effort to optimize the educational program, we have implemented a program of recording lectures to extend the reach to those who are unable to physically attend. We have also found that the static recordings assist fatigued residents in reviewing the material at a more convenient time, enhancing the quality of the educational sessions.

The coauthor (JPL) wanted to investigate the effectiveness of this distance learning approach. Two lectures were recorded and made available to the residents to view at their convenience. A deadline was set to view the recorded lectures and also to complete a quiz to ensure understanding. The residents were also asked to complete an anonymous evaluation of the program to assess satisfaction with and effectiveness of this approach. The results have been promising.

The distance learning approach has been tested and used in other fields such as the nursing field as indicated by the rich literature about distance learning for nursing. Yet the use of this approach in graduate medical education is limited. The schedule and work of a resident are full of competing demands. We believe that this approach will contribute to more effective and satisfactory learning within graduate medical education programs. Distance learning has a number of advantages, and the optimum use of the strategy is yet to be determined.

Sincerely,

  • © Academic Division of Ochsner Clinic Foundation

REFERENCE

  1. ↵
    1. Langford DA,
    2. Bilham TD,
    3. Fellows R,
    4. Newcombe R
    (10, 1994) Case study of development of distance learning course. J Prof Issues Eng Educ Pract 120(4):333–340.
    OpenUrl

Editors' Reply

We agree with Dr Abd-Elsayed that distance learning can be an effective tool for graduate medical education and needs further study and development in medical education.

Professor Wilkinson's editorial titled “The Future of Medical Education: All About Being Connected” in the medical education edition of The Ochsner Journal (Volume 12, Number 4) postulates on the role of technology and distance learning. He suggests that in the future we may see most of a medical school's curriculum delivered through online tools such as recorded lectures, virtual tutorials, and simulation exercises.

We have a way to go, and there are challenges to distance learning in medical education. The “human factor” and the special and unique therapeutic doctor-patient relationship would seem difficult to teach and harder to role model behind the mask of technology. However, we agree it can complement the curriculum, especially considering the current challenges of duty hours, milestones, and an ever-growing body of knowledge.

  • © Academic Division of Ochsner Clinic Foundation

The β-Blockers Crumbling Continues? A Critical Analysis of the REACH Registry

To the Editor:

The study of Bangalore et al questions the validity of one of the mainstays of cardiovascular prevention: the cardioprotective effect of beta blockers (BBs).1 Therefore, it is important to make a critical analysis of some controversial elements of the REduction of Atherothrombosis for Continued Health (REACH) Registry such as the following:

1. The current cohort (44,708 patients) and the subgroup included in the propensity score groups (21,860)1 represent only 65.4% and 32% of the original cohort (68,375).2 Consequently, propensity score is an alternative to the bias of losing one-third of the original cohort.

2. There may be misclassification of cases. In the 1-year follow-up cohort of 68,236 patients, the subgroup with only risk factors was made up of 12,422 patients2 while the current cohort of 44,708 patients paradoxically reported a larger subgroup (18,653 patients) with only risk factors.1

3. The results of REACH might not be valid in all regions studied if we consider that (A) regions with large differences in cardiovascular risk (CVR) were studied (eg, high cardiovascular death rates in Eastern Europe [2.9%] vs low in Japan [0.74%]),2 (B) there was a large regional variability in the use of BBs (63.23% in Eastern Europe vs 18.6% in Japan),2 and (C) important environmental and genetic variables were not quantified in the REACH Registry, which may explain these regional differences of CVR.3

4. CVR predictors are not common in primary (eg, Framingham coronary heart disease scores) and secondary (eg, GRACE [Global Registry of Acute Coronary Events] or OPTIMIZE-HF [Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure] scores) prevention. However, the REACH propensity score uses the same variables in the 3 clinical settings: prior history of myocardial infarction (MI), coronary artery disease but no history of MI, and only risk factors for coronary artery disease.

5. The major criticism of BBs has been associated with lower protection against stroke in primary prevention;4 however, the REACH Registry did not detect this limitation.

6. REACH did not take into account the type and dose of BBs used. BBs are not a homogeneous class, and vasodilating BBs—such as celiprolol, carvedilol, and nebivolol—do not appear to share some of the negative properties described for other compounds (such as atenolol).5 Most of the evidence against atenolol comes from clinical trials (LIFE [Losartan Intervention For Endpoint reduction in hypertension study],6 ASCOT [Anglo-Scandinavian Cardiac Outcomes Trial]7) in which it was used once per day, even though atenolol's half-life is only 18 h.8

7. Other limitations have been recognized by REACH investigators (eg, unmeasured confounding variables).1,2,9

After these and other considerations,10 we have doubts if the BB crumbling continues.11

Sincerely,

  • © Academic Division of Ochsner Clinic Foundation

REFERENCES

  1. ↵
    1. Bangalore S,
    2. Steg G,
    3. Deedwania P,
    4. et al.
    (10 3, 2012) REACH Registry Investigators. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 308(13):1340–1349, pmid:23032550.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Steg PG,
    2. Bhatt DL,
    3. Wilson PW,
    4. et al.
    (3 21, 2007) REACH Registry Investigators. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA 297(11):1197–1206, pmid:17374814.
    OpenUrlCrossRefPubMed
  3. ↵
    1. Lao O,
    2. Dupanloup I,
    3. Barbujani G,
    4. Bertranpetit J,
    5. Calafell F
    (1, 2007) The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. Ann Hum Genet 72(Pt 1):48–56, pmid:17683517, Epub 2007 Aug 7.
    OpenUrlPubMed
  4. ↵
    1. Rothwell PM,
    2. Howard SC,
    3. Dolan E,
    4. et al.
    (5, 2010) ASCOT-BPLA and MRC Trial Investigators. Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 9(5):469–480, pmid:20227347.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Mancia G,
    2. Laurent S,
    3. Agabiti-Rosei E,
    4. et al.
    (11, 2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens 27(11):2121–2158, pmid:19838131.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Dahlöf B,
    2. Devereux RB,
    3. Kjeldsen SE,
    4. et al.
    (3 23, 2002) Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359(9311):995–1003, pmid:11937178.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Dahlöf B,
    2. Sever PS,
    3. Poulter NR,
    4. et al.
    (9 10-16, 2005) ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 366(9489):895–906, pmid:16154016.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Neutel JM,
    2. Schnaper H,
    3. Cheung DG,
    4. Graettinger WF,
    5. Weber MA
    (7, 1990) Antihypertensive effects of beta-blockers administered once daily: 24-hour measurements. Am Heart J 120(1):166–171, pmid:2360502.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Alberts MJ,
    2. Bhatt DL,
    3. Mas JL,
    4. et al.
    (10, 2009) REduction of Atherothrombosis for Continued Health Registry Investigators. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 30(19):2318–2326, pmid:19720633, Epub 2009 Aug 31.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Salinas AM
    (7, 2010) Atenolol in uncomplicated hypertension: time for changes. Lancet Neurol 9(7):652; pmid:20610338, author reply 652-653.
    OpenUrlPubMed
  11. ↵
    1. Lavie CJ,
    2. Messerli FH,
    3. Milani RV
    (9 22, 2009) Beta-blockers as first-line antihypertensive therapy. the crumbling continues. J Am Coll Cardiol 54(13):1162–1164, pmid:19761937.
    OpenUrlFREE Full Text

Reply: Beta Blockers May Be Alive, But on Life Support

We read with interest the comments from Drs Morales Salinas and Coca regarding the widely publicized JAMA paper by Bangalore and colleagues1 on the value (or lack of value) of beta blockers (BBs) in patients with or without coronary heart disease (CHD), which one of us (CJL) commented on in the media the day this was published. Drs Morales Salinas and Coca correctly point out some potential weaknesses of an observational study that would not be present in well-done randomized control trials. Despite these limitations, however, this metaanalysis was performed from a large cohort and was quite well done and certainly raises the idea that BBs may be less useful in the modern era than compared to decades earlier when many of the original studies were performed, during times when patients were not treated as vigorously. In fact, for CHD patients with acute myocardial infarction (AMI), the use of vigorous revascularization, potent antithrombotic therapy, and statins at very high and intense doses has remarkably improved prognosis.2 Likewise, CHD patients in general and those with CHD risk factors are treated much more aggressively than in the past.

Nevertheless, Drs Morales Salinas and Coca make a good point regarding the type of BB. We have recently suggested that carvedilol, for example, is considerably more effective as a BB compared with older agents;3-6 may be appropriate for patients with AMI, stable CHD, and those with CHD risk factors (especially hypertension [HTN]); and may be particularly important for patients with heart failure. In pure HTN, for example, we made the point that the use of older BBs was largely ineffective4,6 and suggested that the “crumbling continues,”6 as Dr Morales Salinas stated. Although BBs may still be alive in preventive cardiology, these agents may be on life support and may need resuscitation in 2013. The use of vasodilating BBs, especially carvedilol, may provide better effectiveness in primary and secondary prevention.

Appendix

Editor's Note: For a summary of the Bangalore et al trial that is the subject of these letters, turn to Advancing Evidence-Based Practice in this issue (page 3). The Bangalore trial is the subject of the first summary.

  • © Academic Division of Ochsner Clinic Foundation

REFERENCES

  1. ↵
    1. Bangalore S,
    2. Steg G,
    3. Deedwania P,
    4. et al.
    (10 3, 2012) REACH Registry Investigators. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 308(13):1340–1349, pmid:23032550.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Lavie CJ,
    2. Milani RV
    (2010) High-dose atorvastatin in acute coronary and cerebrovascular syndromes. J Am Coll Cardiol Intv 3:340–342.
    OpenUrl
  3. ↵
    1. DiNicolantonio JJ,
    2. Hackam DG
    (1, 2012) Carvedilol: a third-generation β-blocker should be a first choice β-blocker. Expert Rev Cardiovasc Ther 10(1):13–25, pmid:22149523.
    OpenUrlCrossRefPubMed
  4. ↵
    1. Fares H,
    2. Lavie CJ,
    3. Ventura HO
    (3, 2012) Vasodilating versus first-generation β-blockers for cardiovascular protection. Postgrad Med 124(2):7–15, pmid:22437211.
    OpenUrlPubMed
    1. DiNicolantonio JJ,
    2. Lavie CJ,
    3. Fares H,
    4. Menezes AR,
    5. O'Keefe JH
    (1 3, 2013) Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol. Am J Cardiol, [Epub ahead of print].
  5. ↵
    1. Lavie CJ,
    2. Messerli FH,
    3. Milani RV
    (9 22, 2009) Beta-blockers as first-line antihypertensive therapy. the crumbling continues. J Am Coll Cardiol 54(13):1162–1164, pmid:19761937.
    OpenUrlFREE Full Text
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Letters to the EditorDistance Learning for Educating Anesthesiology ResidentsEditors' ReplyThe β-Blockers Crumbling Continues? A Critical Analysis of the REACH RegistryReply: Beta Blockers May Be Alive, But on Life Support
Alaa A. Abd-Elsayed, Leonardo Seoane, Alberto Morales Salinas, Carl J. Lavie, John P. Lawrence, Ron Amedee, Antonio Coca, James D. DiNicolantonio, James H. O'Keefe
Ochsner Journal Mar 2013, 13 (1) 166-168;

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Letters to the EditorDistance Learning for Educating Anesthesiology ResidentsEditors' ReplyThe β-Blockers Crumbling Continues? A Critical Analysis of the REACH RegistryReply: Beta Blockers May Be Alive, But on Life Support
Alaa A. Abd-Elsayed, Leonardo Seoane, Alberto Morales Salinas, Carl J. Lavie, John P. Lawrence, Ron Amedee, Antonio Coca, James D. DiNicolantonio, James H. O'Keefe
Ochsner Journal Mar 2013, 13 (1) 166-168;
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