Review ArticleReviews and Commentaries

Functional Genomics in the Study of Mind-Body Therapies

Halsey Niles, Darshan H. Mehta, Alexandra A. Corrigan, Manoj K. Bhasin and John W. Denninger
Ochsner Journal December 2014, 14 (4) 681-695;

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  • Figure 1.
    Figure 1.

    Functional genomics consists of several subfields, defined by their examination of different phases of the cellular cycle. Double helix DNA carries the genetic code, coiling around histone proteins within chromosomes. Epigenomics analyzes modification of histone proteins as well as methylation of regions rich in cytosine-guanine pairings on the DNA strand itself. Transcriptomics involves assessing gene expression by sequencing free-floating messenger RNA strands. Proteomics explores expression levels by identifying and quantifying amounts of circulating proteins. Metabolomics assesses small molecule end-products of cellular processes to quantify the rate at which various processes occur. (Source: Darryl Leja, of the National Human Genome Research Institute. www.genome.gov. Accessed September 23, 2014.)

  • Figure 2.
    Figure 2.

    Trials included in this review by study design type, use of controls, and time course of effects measured.

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