Review ArticleReviews and Commentaries

Functional Genomics in the Study of Mind-Body Therapies

Halsey Niles, Darshan H. Mehta, Alexandra A. Corrigan, Manoj K. Bhasin and John W. Denninger
Ochsner Journal December 2014, 14 (4) 681-695;

REFERENCES

  1. ↵
    1. Russell SJ,
    2. El-Khatib FH,
    3. Sinha M,
    4. et al.
    (7 24, 2014) Outpatient glycemic control with a bionic pancreas in type 1 diabetes. N Engl J Med 371(4):313–325, pmid:24931572.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Kochenderfer JN,
    2. Rosenberg SA
    (5, 2013) Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol 10(5):267–276, pmid:23546520.
    OpenUrlCrossRefPubMed
  3. ↵
    1. Barnes PM,
    2. Bloom B,
    3. Nahin RL
    (2008) Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report (12):1–23, pmid:19361005, Dec 10.
  4. ↵
    1. Nahin RL,
    2. Barnes PM,
    3. Stussman BJ,
    4. Bloom B
    (2009) Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007. Natl Health Stat Report (18):1–14, pmid:19771719, Jul 30.
  5. ↵
    1. Peregoy JA,
    2. Clarke TC,
    3. Jones LI,
    4. Stussman BJ,
    5. Nahin RL
    (4, 2014) Regional variation in use of complementary health approaches by U.S. adults. NCHS Data Brief (146):1–8, pmid:24750666.
  6. ↵
    1. Astin JA,
    2. Shapiro SL,
    3. Eisenberg DM,
    4. Forys KL
    (Mar-Apr 2003) Mind-body medicine: state of the science, implications for practice. J Am Board Fam Pract 16(2):131–147, pmid:12665179.
    OpenUrlAbstract/FREE Full Text
  7. ↵
    1. Benson H,
    2. Beary JF,
    3. Carol MP
    (2, 1974) The relaxation response. Psychiatry 37(1):37–46, pmid:4810622.
    OpenUrlPubMedWeb of Science
  8. ↵
    1. Lazar SW,
    2. Kerr CE,
    3. Wasserman RH,
    4. et al.
    (11 28, 2005) Meditation experience is associated with increased cortical thickness. Neuroreport 16(17):1893–1897, pmid:16272874.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Kang DH,
    2. Jo HJ,
    3. Jung WH,
    4. et al.
    (1, 2013) The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Soc Cogn Affect Neurosci 8(1):27–33, pmid:22569185.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Wells RE,
    2. Yeh GY,
    3. Kerr CE,
    4. et al.
    (11 27, 2013) Meditation's impact on default mode network and hippocampus in mild cognitive impairment: a pilot study. Neurosci Lett 556:15–19, pmid:24120430.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Brewer JA,
    2. Worhunsky PD,
    3. Gray JR,
    4. Tang YY,
    5. Weber J,
    6. Kober H
    (12 13, 2011) Meditation experience is associated with differences in default mode network activity and connectivity. Proc Natl Acad Sci U S A 108(50):20254–20259, pmid:22114193.
    OpenUrlAbstract/FREE Full Text
  12. ↵
    1. Manchanda SC,
    2. Madan K
    (9, 2014) Yoga and meditation in cardiovascular disease. Clin Res Cardiol 103(9):675–680, pmid:24464106, Erratum in: Clin Res Cardiol. 2014 Sep;103(9):763.
    OpenUrlPubMed
  13. ↵
    1. Taylor AG,
    2. Goehler LE,
    3. Galper DI,
    4. Innes KE,
    5. Bourguignon C
    (Jan-Feb 2010) Top-down and bottom-up mechanisms in mind-body medicine: development of an integrative framework for psychophysiological research. Explore (NY) 6(1):29–41, pmid:20129310.
    OpenUrlPubMed
  14. ↵
    1. Dusek JA,
    2. Hibberd PL,
    3. Buczynski B,
    4. et al.
    (3, 2008) Stress management versus lifestyle modification on systolic hypertension and medication elimination: a randomized trial. J Altern Complement Med 14(2):129–138, pmid:18315510.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Kearney DJ,
    2. Brown-Chang J
    (11, 2008) Complementary and alternative medicine for IBS in adults: mind-body interventions. Nat Clin Pract Gastroenterol Hepatol 5(11):624–636, pmid:18825145.
    OpenUrlPubMedWeb of Science
  16. ↵
    1. Sarris J,
    2. Byrne GJ
    (4, 2011) A systematic review of insomnia and complementary medicine. Sleep Med Rev 15(2):99–106, pmid:20965131.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Astin JA
    (Jan-Feb 2004) Mind-body therapies for the management of pain. Clin J Pain 20(1):27–32, pmid:14668653.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Chiesa A,
    2. Serretti A
    (1, 2011) Mindfulness-based interventions for chronic pain: a systematic review of the evidence. J Altern Complement Med 17(1):83–93, pmid:21265650.
    OpenUrlCrossRefPubMed
  19. ↵
    1. D'Silva S,
    2. Poscablo C,
    3. Habousha R,
    4. Kogan M,
    5. Kligler B
    (Sep-Oct 2012) Mind-body medicine therapies for a range of depression severity: a systematic review. Psychosomatics 53(5):407–423, pmid:22902090.
    OpenUrlPubMed
  20. ↵
    1. Marchand WR
    (3, 2013) Mindfulness meditation practices as adjunctive treatments for psychiatric disorders. Psychiatr Clin North Am 36(1):141–152, pmid:23538083.
    OpenUrlPubMed
  21. ↵
    1. Goyal M,
    2. Singh S,
    3. Sibinga EM,
    4. et al.
    (3, 2014) Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med 174(3):357–368, pmid:24395196.
    OpenUrlCrossRefPubMedWeb of Science
  22. ↵
    1. Kim SH,
    2. Schneider SM,
    3. Kravitz L,
    4. Mermier C,
    5. Burge MR
    (6, 2013) Mind-body practices for posttraumatic stress disorder. J Investig Med 61(5):827–834.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Brook RD,
    2. Appel LJ,
    3. Rubenfire M,
    4. et al.
    (6, 2013) Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the American Heart Association. Hypertension 61(6):1360–1383, pmid:23608661.
    OpenUrlAbstract/FREE Full Text
  24. ↵
    1. Saatcioglu F
    (2, 2013) Regulation of gene expression by yoga, meditation and related practices: a review of recent studies. Asian J Psychiatr 6(1):74–77, pmid:23380323.
    OpenUrlPubMed
  25. ↵
    1. Kaelin WG Jr.,
    2. McKnight SL
    (3 28, 2013) Influence of metabolism on epigenetics and disease. Cell 153(1):56–69, pmid:23540690.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Lee JT
    (12 14, 2012) Epigenetic regulation by long noncoding RNAs. Science 338(6113):1435–1439, pmid:23239728.
    OpenUrlAbstract/FREE Full Text
  27. ↵
    1. Daxinger L,
    2. Whitelaw E
    (1 31, 2012) Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet 13(3):153–162, pmid:22290458.
    OpenUrlCrossRefPubMed
  28. ↵
    1. Guerrero-Bosagna C,
    2. Skinner MK
    (5 6, 2012) Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Mol Cell Endocrinol 354(1-2):3–8, pmid:22020198.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Pick H,
    2. Kilic S,
    3. Fierz B
    (8, 2014) Engineering chromatin states: chemical and synthetic biology approaches to investigate histone modification function. Biochim Biophys Acta 1839(8):644–656, pmid:24768924.
    OpenUrlPubMed
  30. ↵
    1. Smith ZD,
    2. Meissner A
    (3, 2013) DNA methylation: roles in mammalian development. Nat Rev Genet 14(3):204–220, pmid:23400093.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Hu WS,
    2. Zeng AP
    1. Stahl F,
    2. Hitzmann B,
    3. Mutz K,
    4. et al.
    (2012) in Genomics and Systems Biology of Mammalian Cell Culture in Advances in Biochemical Engineering/Biotechnology, Transcriptome analysis, eds Hu WS, Zeng AP (Springer; New York, NY) In, eds, Vol, 127, pp 1–25.
    OpenUrlPubMed
  32. ↵
    1. Skibsted S,
    2. Bhasin MK,
    3. Aird WC,
    4. Shapiro NI
    (10 4, 2013) Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach. Crit Care 17(5):231, pmid:24093155.
    OpenUrlPubMed
  33. ↵
    1. Cole SW
    (8, 2010) Elevating the perspective on human stress genomics. Psychoneuroendocrinology 35(7):955–962, pmid:20630660.
    OpenUrlCrossRefPubMedWeb of Science
  34. ↵
    1. Wang E,
    2. Lenferink A,
    3. O'Connor-McCourt M
    (7, 2007) Cancer systems biology: exploring cancer-associated genes on cellular networks. Cell Mol Life Sci 64(14):1752–1762, pmid:17415519.
    OpenUrlCrossRefPubMedWeb of Science
  35. ↵
    1. Rossi E,
    2. Iannotti S,
    3. Cozzolino M,
    4. Castiglione S,
    5. Cicatelli A,
    6. Rossi K
    (2008) A pilot study of positive expectations and focused attention via a new protocol for optimizing therapeutic hypnosis and psychotherapy assessed with DNA microarrays: the creative psychosocial genomic healing experience. Sleep Hypn 10(2):39–44.
    OpenUrl
  36. ↵
    1. Li QZ,
    2. Li P,
    3. Garcia GE,
    4. Johnson RJ,
    5. Feng L
    (2, 2005) Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction. J Altern Complement Med 11(1):29–39, pmid:15750361.
    OpenUrlPubMed
  37. ↵
    1. Sharma H,
    2. Datta P,
    3. Singh A,
    4. et al.
    (2, 2008) Gene expression profiling in practitioners of Sudarshan Kriya. J Psychosom Res 64(2):213–218, pmid:18222135.
    OpenUrlCrossRefPubMed
  38. ↵
    1. Kumar A,
    2. Balkrishna A
    (11, 2009) To study the effect of the sequence of seven pranayama by Swami Ramdev on gene expression in leukaemia patients and rapid interpretation of gene expression. J Clin Pathol 62(11):1052–1053, pmid:19861570.
    OpenUrlFREE Full Text
  39. ↵
    1. Ren H,
    2. Collins V,
    3. Clarke SJ,
    4. et al.
    (2012) Epigenetic changes in response to tai chi practice: a pilot investigation of DNA methylation marks. Evid Based Complement Alternat Med 2012:841810, pmid:22719790.
    OpenUrlPubMed
  40. ↵
    1. Antoni MH,
    2. Lutgendorf SK,
    3. Blomberg B,
    4. et al.
    (2 15, 2012) Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biol Psychiatry 71(4):366–372, pmid:22088795.
    OpenUrlCrossRefPubMedWeb of Science
  41. ↵
    1. Bower JE,
    2. Greendale G,
    3. Crosswell AD,
    4. et al.
    (5, 2014) Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial. Psychoneuroendocrinology 43:20–29, pmid:24703167.
    OpenUrlCrossRefPubMed
  42. ↵
    1. Creswell JD,
    2. Irwin MR,
    3. Burklund LJ,
    4. et al.
    (10, 2012) Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun 26(7):1095–1101, pmid:22820409.
    OpenUrlCrossRefPubMed
  43. ↵
    1. Yang KD,
    2. Chang WC,
    3. Chuang H,
    4. Wang PW,
    5. Liu RT,
    6. Yeh SH
    (1, 2010) Increased complement factor H with decreased factor B determined by proteomic differential displays as a biomarker of tai chi chuan exercise. Clin Chem 56(1):127–131, pmid:19884489.
    OpenUrlAbstract/FREE Full Text
  44. ↵
    1. Black DS,
    2. Cole SW,
    3. Irwin MR,
    4. et al.
    (3, 2013) Yogic meditation reverses NF-kappaB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology 38(3):348–355, pmid:22795617.
    OpenUrlCrossRefPubMedWeb of Science
  45. ↵
    1. Qu S,
    2. Olafsrud SM,
    3. Meza-Zepeda LA,
    4. Saatcioglu F
    (2013) Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program. PLoS One 8(4), Apr 17, e61910.
  46. ↵
    1. Ravnik-Glavač M,
    2. Hrašovec S,
    3. Bon J,
    4. Dreo J,
    5. Glavač D
    (9, 2012) Genome-wide expression changes in a higher state of consciousness. Conscious Cogn 21(3):1322–1344, pmid:22742996.
    OpenUrlPubMed
  47. ↵
    1. Kaliman P,
    2. Alvarez-López MJ,
    3. Cosín-Tomás M,
    4. Rosenkranz MA,
    5. Lutz A,
    6. Davidson RJ
    (2, 2014) Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology 40:96–107, pmid:24485481.
    OpenUrlCrossRefPubMed
  48. ↵
    1. Bhasin MK,
    2. Dusek JA,
    3. Chang BH,
    4. et al.
    (2013) Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One 8(5), May 1, e62817.
  49. ↵
    1. Del Prete A,
    2. Allavena P,
    3. Santoro G,
    4. Fumarulo R,
    5. Corsi MM,
    6. Mantovani A
    (2011) Molecular pathways in cancer-related inflammation. Biochem Med (Zagreb) 21(3):264–275, pmid:22420240.
    OpenUrlCrossRefPubMed
    1. Mantovani A,
    2. Allavena P,
    3. Sica A,
    4. Balkwill F
    (7 24, 2008) Cancer-related inflammation. Nature 454(7203):436–444, pmid:18650914.
    OpenUrlCrossRefPubMedWeb of Science
  51. ↵
    1. Yamamoto Y,
    2. Gaynor RB
    (1, 2001) Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 107(2):135–142, pmid:11160126.
    OpenUrlCrossRefPubMedWeb of Science
  52. ↵
    1. Miller GE,
    2. Chen E,
    3. Sze J,
    4. et al.
    (8 15, 2008) A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry 64(4):266–272, pmid:18440494.
    OpenUrlCrossRefPubMedWeb of Science
  53. ↵
    1. Bouwmeester T,
    2. Bauch A,
    3. Ruffner H,
    4. et al.
    (2, 2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6(2):97–105, pmid:14743216.
    OpenUrlCrossRefPubMedWeb of Science
  54. ↵
    1. Dusek JA,
    2. Otu HH,
    3. Wohlhueter AL,
    4. et al.
    (2008) Genomic counter-stress changes induced by the relaxation response. PLoS One 3(7), Jul 2, e2576.
  55. ↵
    1. Kiecolt-Glaser JK,
    2. Preacher KJ,
    3. MacCallum RC,
    4. Atkinson C,
    5. Malarkey WB,
    6. Glaser R
    (7 22, 2003) Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A 100(15):9090–9095, pmid:12840146.
    OpenUrlAbstract/FREE Full Text
  56. ↵
    1. Prakhinkit S,
    2. Suppapitiporn S,
    3. Tanaka H,
    4. Suksom D
    (5, 2014) Effects of Buddhism walking meditation on depression, functional fitness, and endothelium-dependent vasodilation in depressed elderly. J Altern Complement Med 20(5):411–416, pmid:24372522.
    OpenUrlCrossRefPubMed
  57. ↵
    1. Yadav RK,
    2. Magan D,
    3. Mehta N,
    4. Sharma R,
    5. Mahapatra SC
    (7, 2012) Efficacy of a short-term yoga-based lifestyle intervention in reducing stress and inflammation: preliminary results. J Altern Complement Med 18(7):662–667, pmid:22830969.
    OpenUrlCrossRefPubMed
    1. Sarvottam K,
    2. Magan D,
    3. Yadav RK,
    4. Mehta N,
    5. Mahapatra SC
    (5, 2013) Adiponectin, interleukin-6, and cardiovascular disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men. J Altern Complement Med 19(5):397–402, pmid:23210469.
    OpenUrlCrossRefPubMed
    1. Pullen PR,
    2. Nagamia SH,
    3. Mehta PK,
    4. et al.
    (6, 2008) Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure. J Card Fail 14(5):407–413, pmid:18514933.
    OpenUrlCrossRefPubMedWeb of Science
  60. ↵
    1. Pullen PR,
    2. Thompson WR,
    3. Benardot D,
    4. et al.
    (4, 2010) Benefits of yoga for African American heart failure patients. Med Sci Sports Exerc 42(4):651–657, pmid:19952833.
    OpenUrlPubMed
  61. ↵
    1. Kiecolt-Glaser JK,
    2. Christian L,
    3. Preston H,
    4. et al.
    (2, 2010) Stress, inflammation, and yoga practice. Psychosom Med 72(2):113–121, pmid:20064902.
    OpenUrlAbstract/FREE Full Text
  62. ↵
    1. Gallegos AM,
    2. Hoerger M,
    3. Talbot NL,
    4. et al.
    (10, 2013) Toward identifying the effects of the specific components of Mindfulness-Based Stress Reduction on biologic and emotional outcomes among older adults. J Altern Complement Med 19(10):787–792, pmid:23383976.
    OpenUrlCrossRefPubMed
    1. Rosenkranz MA,
    2. Davidson RJ,
    3. Maccoon DG,
    4. Sheridan JF,
    5. Kalin NH,
    6. Lutz A
    (1, 2013) A comparison of Mindfulness-Based Stress Reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun 27(1):174–184, pmid:23092711.
    OpenUrlCrossRefPubMed
  64. ↵
    1. Malarkey WB,
    2. Jarjoura D,
    3. Klatt M
    (1, 2013) Workplace based mindfulness practice and inflammation: a randomized trial. Brain Behav Immun 27(1):145–154, pmid:23078984.
    OpenUrlCrossRefPubMed
  65. ↵
    1. Pace TW,
    2. Negi LT,
    3. Adame DD,
    4. et al.
    (1, 2009) Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology 34(1):87–98, pmid:18835662.
    OpenUrlCrossRefPubMedWeb of Science
  66. ↵
    1. Janelsins MC,
    2. Davis PG,
    3. Wideman L,
    4. et al.
    (6, 2011) Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors. Clin Breast Cancer 11(3):161–170, pmid:21665136.
    OpenUrlCrossRefPubMedWeb of Science
  67. ↵
    1. Jones BM
    (2001) Changes in cytokine production in healthy subjects practicing Guolin Qigong: a pilot study. BMC Complement Altern Med 1:8, pmid:11696251.
    OpenUrlCrossRefPubMed
  68. ↵
    1. Carlson LE,
    2. Speca M,
    3. Faris P,
    4. Patel KD
    (11, 2007) One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of Mindfulness-Based Stress Reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun 21(8):1038–1049, pmid:17521871.
    OpenUrlCrossRefPubMedWeb of Science
  69. ↵
    1. Carlson LA,
    2. Tighe SW,
    3. Kenefick RW,
    4. Dragon J,
    5. Westcott NW,
    6. Leclair RJ
    (12, 2011) Changes in transcriptional output of human peripheral blood mononuclear cells following resistance exercise. Eur J Appl Physiol 111(12):2919–2929, pmid:21437602.
    OpenUrlCrossRefPubMed
  70. ↵
    1. Gano LB,
    2. Donato AJ,
    3. Pierce GL,
    4. et al.
    (7 27, 2011) Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics 43(14):895–902, pmid:21610086.
    OpenUrlCrossRefPubMedWeb of Science
  71. ↵
    1. Neubauer O,
    2. Reichhold S,
    3. Nics L,
    4. et al.
    (10, 2010) Antioxidant responses to an acute ultra-endurance exercise: impact on DNA stability and indications for an increased need for nutritive antioxidants in the early recovery phase. Br J Nutr 104(8):1129–1138, pmid:20637132.
    OpenUrlCrossRefPubMed
    1. Nakamura S,
    2. Kobayashi M,
    3. Sugino T,
    4. Kajimoto O,
    5. Matoba R,
    6. Matsubara K
    (1 1, 2010) Effect of exercise on gene expression profile in unfractionated peripheral blood leukocytes. Biochem Biophys Res Commun 391(1):846–851, pmid:19945435.
    OpenUrlPubMed
    1. Büttner P,
    2. Mosig S,
    3. Lechtermann A,
    4. Funke H,
    5. Mooren FC
    (1, 2007) Exercise affects the gene expression profiles of human white blood cells. J Appl Physiol (1985) 102(1):26–36, pmid:16990507.
    OpenUrlCrossRefPubMedWeb of Science
    1. Sakharov DA,
    2. Maltseva DV,
    3. Riabenko EA,
    4. et al.
    (3, 2012) Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells. Eur J Appl Physiol 112(3):963–972, pmid:21717121.
    OpenUrlPubMed
  75. ↵
    1. Radom-Aizik S,
    2. Leu SY,
    3. Cooper DM,
    4. Zaldivar F Jr.
    (11, 2007) Serum from exercising humans suppresses t-cell cytokine production. Cytokine 40(2):75–81, pmid:17919919.
    OpenUrlPubMed
  76. ↵
    1. Denham J,
    2. Marques FZ,
    3. O'Brien BJ,
    4. Charchar FJ
    (2, 2014) Exercise: putting action into our epigenome. Sports Med 44(2):189–209, pmid:24163284.
    OpenUrlCrossRefPubMedWeb of Science
  77. ↵
    1. Noto Y,
    2. Kudo M,
    3. Hirota K
    (12, 2010) Back massage therapy promotes psychological relaxation and an increase in salivary chromogranin A release. J Anesth 24(6):955–958, pmid:20683736.
    OpenUrlCrossRefPubMedWeb of Science
    1. Hillier SL,
    2. Louw Q,
    3. Morris L,
    4. Uwimana J,
    5. Statham S
    (2010) Massage therapy for people with HIV/AIDS. Cochrane Database Syst Rev (1), Jan 20, CD007502.
    1. Rapaport MH,
    2. Schettler P,
    3. Bresee C
    (10 18, 2010) A preliminary study of the effects of a single session of Swedish massage on hypothalamic-pituitary-adrenal and immune function in normal individuals. J Altern Complement Med 16(10):1079–1088, pmid:20809811.
    OpenUrlCrossRefPubMed
  80. ↵
    1. Donoyama N,
    2. Ohkoshi N
    (6, 2011) Effects of traditional Japanese massage therapy on gene expression: preliminary study. J Altern Complement Med 17(6):553–555, pmid:21595543.
    OpenUrlCrossRefPubMed
  81. ↵
    1. Bittman B,
    2. Berk L,
    3. Shannon M,
    4. et al.
    (2, 2005) Recreational music-making modulates the human stress response: a preliminary individualized gene expression strategy. Med Sci Monit 11(2):BR31–BR40, pmid:15668624.
    OpenUrlPubMed
  82. ↵
    1. Jia J,
    2. Yu Y,
    3. Deng JH,
    4. et al.
    (4 10, 2012) A review of Omics research in acupuncture: the relevance and future prospects for understanding the nature of meridians and acupoints. J Ethnopharmacol 140(3):594–603, pmid:22322253.
    OpenUrlPubMed
  83. ↵
    1. Morita K,
    2. Saito T,
    3. Ohta M,
    4. et al.
    (6 10-17, 2005) Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett 381(1-2):57–62, pmid:15882790.
    OpenUrlPubMed
  84. ↵
    1. O'Donovan A,
    2. Sun B,
    3. Cole S,
    4. et al.
    (2011) Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers 30(2-3):123–132, pmid:21508516.
    OpenUrlCrossRefPubMedWeb of Science
  85. ↵
    1. Segman RH,
    2. Shefi N,
    3. Goltser-Dubner T,
    4. Friedman N,
    5. Kaminski N,
    6. Shalev AY
    (5, 2005) Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry Mol Psychiatry 10, 10(5), (5):500–513, 425, 514, pmid:15685253, Erratum in, 2005 May.
    OpenUrlCrossRefPubMedWeb of Science
  86. ↵
    1. Bhasin M,
    2. Dusek J,
    3. Chang BH,
    4. Fricchione G,
    5. Benson H,
    6. Libermann T
    (Fall 2009) 6th Annual International Conference of the Society for Integrative Oncology J Soc Integr Oncol, Genomic changes induced by the relaxation response counter genomic dysregulation of several cancers [abstract M35], (New York, NY) November 12-13, 2009, 7, 4, pp 173–186.
    OpenUrl
  87. ↵
    1. McEwen BS,
    2. Eiland L,
    3. Hunter RG,
    4. Miller MM
    (1, 2012) Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 62(1):3–12, pmid:21807003.
    OpenUrlCrossRefPubMedWeb of Science
  88. ↵
    1. Bojesen SE
    (11, 2013) Telomeres and human health. J Intern Med 274(5):399–413, pmid:24127938.
    OpenUrlCrossRefPubMed
  89. ↵
    1. Epel ES,
    2. Blackburn EH,
    3. Lin J,
    4. et al.
    (12 7, 2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 101(49):17312–17315, pmid:15574496.
    OpenUrlAbstract/FREE Full Text
  90. ↵
    1. Epel ES,
    2. Lin J,
    3. Wilhelm FH,
    4. et al.
    (4, 2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31(3):277–287, pmid:16298085.
    OpenUrlCrossRefPubMedWeb of Science
  91. ↵
    1. Ornish D,
    2. Lin J,
    3. Daubenmier J,
    4. et al.
    (11, 2008) Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol 9(11):1048–1057, pmid:18799354, Erratum in: Lancet Oncol. 2008 Dec;9(12):1124.
    OpenUrlCrossRefPubMedWeb of Science
  92. ↵
    1. Ornish D,
    2. Lin J,
    3. Chan JM,
    4. et al.
    (10, 2013) Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol 14(11):1112–1120, pmid:24051140.
    OpenUrlCrossRefPubMedWeb of Science
  93. ↵
    1. Ho RT,
    2. Chan JS,
    3. Wang CW,
    4. et al.
    (10, 2012) A randomized controlled trial of qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome. Ann Behav Med 44(2):160–170, pmid:22736201.
    OpenUrlCrossRefPubMed
  94. ↵
    1. Jacobs TL,
    2. Epel ES,
    3. Lin J,
    4. et al.
    (6, 2011) Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology 36(5):664–681, pmid:21035949.
    OpenUrlCrossRefPubMedWeb of Science
  95. ↵
    1. Daubenmier J,
    2. Lin J,
    3. Blackburn E,
    4. et al.
    (7, 2012) Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology 37(7):917–928, pmid:22169588.
    OpenUrlCrossRefPubMedWeb of Science
  96. ↵
    1. Hoge EA,
    2. Chen MM,
    3. Orr E,
    4. et al.
    (8, 2013) Loving-Kindness Meditation practice associated with longer telomeres in women. Brain Behav Immun 32:159–163, pmid:23602876.
    OpenUrlCrossRefPubMed
  97. ↵
    1. Braun MM
    (10, 2013) Temporary practice pause then resumption (TPPR) study design: an extension of the withdrawal study design to complementary and alternative medicine mind and body interventions (CAM-MABI). J Altern Complement Med 19(10):833–837, pmid:23682588.
    OpenUrlPubMed
  98. ↵
    1. Benson H
    (1983) The relaxation response: its subjective and objective historical precedents and physiology. TINS 6:281–284.
    OpenUrlCrossRefWeb of Science
  99. ↵
    1. Mandle CL,
    2. Jacobs SC,
    3. Arcari PM,
    4. Domar AD
    (4, 1996) The efficacy of relaxation response interventions with adult patients: a review of the literature. J Cardiovasc Nurs 10(3):4–26, pmid:8820317.
    OpenUrlCrossRefPubMed
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools

Jump to section

Keywords