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Research ArticleORIGINAL RESEARCH

Effect of Obesity on Component Alignment in Total Knee Arthroplasty

Connor Ojard, Alexander Habashy, Mark Meyer, George Chimento and John L. Ochsner
Ochsner Journal September 2018, 18 (3) 226-229; DOI: https://doi.org/10.31486/toj.18.0005
Connor Ojard
1Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA
2The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA
MD
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Alexander Habashy
1Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA
2The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA
MD
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Mark Meyer
1Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA
2The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA
MD
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  • For correspondence: msmeyer@ochsner.org
George Chimento
1Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA
2The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA
MD
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John L. Ochsner
1Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA
2The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA
MD
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Abstract

Background: Obesity is routinely cited as a negative predictive factor for outcomes after total knee arthroplasty (TKA), but the direct mechanism responsible for this relationship has not been described. One possible explanation is a propensity for component malalignment in obese patients that is attributable to difficulty with surgical exposure.

Methods: This study evaluated the effect of obesity on TKA component alignment in 251 primary TKAs during a 12-month period at a single center in 2009. Postoperative component alignment was retrospectively measured and compared between patients defined as obese (body mass index [BMI] ≥30 kg/m2) and patients defined as nonobese (BMI <30 kg/m2). Alignment was determined by measuring the coronal tibiofemoral angle, coronal femoral component angle, coronal tibial component angle, sagittal femoral component angle, and sagittal tibial component angle in all of the study patients.

Results: Statistical analysis failed to demonstrate a statistically significant relationship between obesity and component alignment in any of the measured parameters.

Conclusion: The results of this study support that obesity does not negatively affect TKA component alignment; another factor must be associated with the worse outcomes in obese patients undergoing TKA.

Keywords:
  • Body mass index
  • obesity
  • total knee arthroplasty

INTRODUCTION

Total knee arthroplasty (TKA) is widely regarded as one of the most successful orthopedic surgical procedures.1,2 The orthopedic literature's commonly quoted 15-year TKA survival rate of approximately 90%1-4 is dependent upon patient-related factors,5,6 prosthesis-related factors,7 and surgical technique–related factors.8 Although the morbidity and mortality associated with the patient-related factor of obesity are well recognized in the medical literature,9-11 the current orthopedic literature exploring the specific nature of this relationship is inconclusive, with some studies finding little difference in outcomes and others demonstrating inferior results.3,4,12-21

An important surgical technique–related factor is femoral and tibial component alignment.22 Malpositioning of either component has been associated with the failure of TKAs secondary to aseptic loosening, instability, polyethylene wear, and dislocation of the patella.22-25 The aim of this study was to evaluate the relationship between the patient-related factor of obesity and the surgical technique–related factor of TKA component alignment.

METHODS

After obtaining institutional review board approval, retrospective data were collected on 320 consecutive primary cemented posterior cruciate-substituting total knee replacements (equipment providers Zimmer Biomet, Exactech Inc., and Stryker Corporation) performed by 3 surgeons (M.M., G.C., and J.L.O.) during a 12-month period beginning in January 2009. All surgeons used a standard surgical technique for TKA, including medial parapatellar arthrotomy and soft tissue releases as indicated. Intramedullary femoral cutting guides with posterior referencing and extramedullary tibial cutting guides were used to verify alignment intraoperatively. All components after trial fitting were secured with bone cement in a standard fashion. During the trial period, none of the surgeons made any significant changes to his surgical techniques. Standard postoperative radiographs of the included patients were appraised by a postgraduate year 5 orthopedic surgery resident who was blinded to the patients' body mass index (BMI). Five commonly accepted radiographic measurements were obtained: the coronal tibiofemoral angle (CTFA), the coronal femoral component angle (CFCA), the coronal tibial component angle (CTCA), the sagittal femoral component angle (SFCA), and the sagittal tibial component angle (STCA) (Figures 1 and 2).

Figure 1.
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Figure 1. Radiographic determination of coronal alignment in total knee arthroplasty. Coronal tibiofemoral (left), femoral (middle), and tibial (right) measurements are shown.
Figure 2.
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Figure 2. Radiographic determination of sagittal alignment in total knee arthroplasty. Sagittal femoral (left) and tibial (right) measurements are shown.

BMI was calculated for each patient using a standardized formula (kg/m2) based on data entered into the medical record at the most recent preoperative assessment, which for most patients was the morning of surgery. The World Health Organization has defined obesity as a BMI ≥30 kg/m2. For purposes of the study, patients were categorized as either obese (BMI ≥30 kg/m2) or nonobese (BMI <30 kg/m2).

Chi-square analysis was used to investigate potential group differences for the categorical variables of sex and involved lower extremity between the obese and nonobese groups. Independent t tests were used to evaluate potential differences for the continuous variables of age, CTFA, CFCA, CTCA, SFCA, and STCA. Statistical significance was set at P < 0.05, and the statistical tests were performed using online GraphPad Software.

RESULTS

Two hundred and fifty-one knees in 153 patients had adequate postoperative radiographs to allow inclusion in the study. Of these, 49 patients underwent bilateral TKAs. Based on BMI values, 149 knees were included in the obese group and 102 knees were included in the nonobese group. Demographic characteristics of the two groups are shown in Table 1. The differences in sex and laterality between the obese and nonobese groups were not significant (P = 0.2943 and P = 0.7013, respectively). The mean ages in the 2 groups were 63.9 years in the obese group and 71.4 in the nonobese group. The difference in ages was statistically significant (P < 0.001).

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Table 1. Baseline Demographic Data

Table 2 shows the component alignment measurements in the 2 groups. The mean CTFA was 184.1° for the obese group and 184.7° for the nonobese group. The mean CFCA was 94.6° for the obese group and 95.9° for the nonobese group. The mean CTCA was 89.7° for the obese group and 89.8° for the nonobese group. The differences in all 3 coronal alignment measurements were not statistically significant (P = 0.0556, P = 0.2246, and P = 0.7264, respectively).

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Table 2. Component Alignment Measurements by Group

The mean SFCA was 84.7° for the obese group and 85.1° for the nonobese group. The mean STCA was 86.6° for the obese group and 86.5° for the nonobese group. The differences in the 2 sagittal alignment measurements were also not statistically significant (P = 0.5223 and P = 0.7059, respectively).

DISCUSSION

Our data show that overall alignment in TKA does not appear to be affected by obesity as we found no statistically significant relationship between obesity and TKA coronal and sagittal alignment measurements. This finding is important as obesity is generally recognized to be associated with worse outcomes, as well as increased morbidity and mortality, in TKA.

Merle-Vincent et al presented data on a series of 264 patients in a prospective multicenter study that sought to identify factors predicting patient satisfaction 2 years after TKA for osteoarthritis.5 Factors significantly associated with good satisfaction in the multivariate model included age >70 years, severe joint space narrowing, absence of depression at the 2-year evaluation, and a BMI <27 kg/m2.

Järvenpää et al presented data on a series of 100 patients in a prospective study that looked at the short-term outcome of obese (BMI ≥30 kg/m2) and nonobese (BMI <30 kg/m2) TKA patients using clinical, functional, and radiologic analysis.21 They noted a higher rate of complications, worse postoperative range of motion, and an increased number of technical errors in the obese group and concluded that obesity may impair early outcomes of TKA and that obese patients should be educated regarding the increased complications.

As noted earlier, many factors influence the outcome of TKA including patient-related factors,5,6 prosthesis-related factors,7 and surgical technique–related factors.8 As we did not find that obesity had a significant effect on mechanical alignment in TKA, another factor may be associated with worsened outcomes in obese patients. Further investigation is necessary to determine why these individuals appear to have worse outcomes after TKA.

One limitation of this study is that all 3 surgeons used different arthroplasty devices. Use of the different guides made for the three devices may be a confounding factor. Also, during the study period, a higher proportion of obese subjects had TKA compared to nonobese subjects. This difference may be related to both the pathoanatomy of degenerative joint disease and the patient population of the study center. Finally, the difference in age in the obese group compared to the nonobese group (average age 63.9 vs 71.4 years) may be a confounding factor secondary to decreased bone quality with advanced age and is a factor to be further investigated. The strengths of this study include the number of patients included in the analysis and the reproducibility of the radiographic parameters.

CONCLUSION

In our study, we found no relationship between obesity and TKA component alignment. This finding suggests that mechanically, arthroplasty can be performed at the same level of accuracy and precision in obese patients as in nonobese patients. Because obesity is negatively associated with patient outcome following TKA, another variable other than component position may be the causal factor.

This article meets the Accreditation Council for Graduate Medical Education and the American Board of Medical Specialties Maintenance of Certification competencies for Patient Care and Medical Knowledge.

ACKNOWLEDGMENTS

Dr George Chimento is a consultant for Stryker Corporation. Otherwise, the authors have no financial or proprietary interest in the subject matter of this article.

  • © Academic Division of Ochsner Clinic Foundation

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Effect of Obesity on Component Alignment in Total Knee Arthroplasty
Connor Ojard, Alexander Habashy, Mark Meyer, George Chimento, John L. Ochsner
Ochsner Journal Sep 2018, 18 (3) 226-229; DOI: 10.31486/toj.18.0005

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Effect of Obesity on Component Alignment in Total Knee Arthroplasty
Connor Ojard, Alexander Habashy, Mark Meyer, George Chimento, John L. Ochsner
Ochsner Journal Sep 2018, 18 (3) 226-229; DOI: 10.31486/toj.18.0005
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