Research ArticleORIGINAL RESEARCH

Transforming Growth Factor Beta 1 Regulates Fibroblast Growth Factor 7 Expression in Schwann Cells

Doan Nguyen and Olawale A. R. Sulaiman
Ochsner Journal March 2019, 19 (1) 7-12; DOI: https://doi.org/10.31486/toj.18.0106

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  • Figure 1.
    Figure 1.

    Immunocytochemical detection of (A) S100B and (B) fibroblast growth factor 7 (FGF-7) in primary Schwann cells (SCs) isolated from rat sciatic nerves. The positive staining indicates that these SCs are S100B-positive and express FGF-7 (×10).

  • Figure 2.
    Figure 2.

    Fold changes (FC) in expression of fibroblast growth factor 7 (FGF-7), myelin basic protein (MBP), and peripheral myelin protein 22 (PMP-22) relative to untreated controls (Con) after 24-hour treatment with forskolin (Fsk), transforming growth factor beta 1 (TGFB), or transforming growth factor beta 1 + forskolin (T/F). Expression of FGF-7 and MBP significantly decreased with TGFB and T/F treatments (n=3, P<0.05).

  • Figure 3.
    Figure 3.

    Fold changes (FC) in expression of fibroblast growth factor 7 (FGF-7), myelin basic protein (MBP), and peripheral myelin protein 22 (PMP-22) relative to untreated controls (Con). Schwann cells were stimulated with transforming growth factor beta 1 (TGF-β1) + forskolin (T/F) alone or with T/F and LY2109761 (T/F+I), a TGF-β receptor type I/II (TβR1/II) inhibitor, for 6 hours (n=3). Blocking of TβR1/II decreased the effect of T/F treatment on FGF-7 expression (P<0.05).

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