Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
  • About Us
    • About the Ochsner Journal
    • Editorial Board
  • More
    • Alerts
    • Feedback
  • Other Publications
    • Ochsner Journal Blog

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Ochsner Journal
  • Other Publications
    • Ochsner Journal Blog
  • My alerts
  • Log in
Ochsner Journal

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
  • About Us
    • About the Ochsner Journal
    • Editorial Board
  • More
    • Alerts
    • Feedback
Research ArticleORIGINAL RESEARCH
Open Access

Rates of Cognitive Decline in 100 Patients With Alzheimer Disease

Monica Miyakawa-Liu, Amy K. Feehan, Shannon Pai and Julia Garcia-Diaz
Ochsner Journal June 2022, 22 (2) 129-133; DOI: https://doi.org/10.31486/toj.21.0084
Monica Miyakawa-Liu
1Department of Pathology, Stanford University, Stanford, CT
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy K. Feehan
2Department of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, LA
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: amy.feehan{at}ochsner.org
Shannon Pai
3The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA
BS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia Garcia-Diaz
2Department of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, LA
3The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure.

    Average annual decline in Mini-Mental State Examination (MMSE) scores in smokers vs nonsmokers.

Tables

  • Figures
    • View popup
    Table 1.

    Clinical and Demographic Data for All Patients

    VariablePatients with Alzheimer Disease, n=100
    Mini-Mental State Examination score, mean (SD)22.63 (5.77)
    Montreal Cognitive Assessment score, mean (SD)18.19 (5.56)
    Decline in Mini-Mental State Examination score per year, mean (SD)2.43 (2.82)
    Decline in Montreal Cognitive Assessment score per year, mean (SD)2.39 (1.88)
    Age at diagnosis, years, mean (SD)74.75 (7.67)
    Male41 (41)
    Marital status
     Married61 (61)
     Widowed28 (28)
     Single5 (5)
     Divorced4 (4)
     Other2 (2)
    Race
     White73 (73)
     Nonwhite (Black, Hispanic)27 (27)
    Vascular risk factors
     Diabetes mellitus29 (29)
     Cerebrovascular accident13 (13)
     Smoking40 (40)
    Alcohol36 (36)
    Hypothyroidism19 (19)
    Major depressive disorder34 (34)
    • Note: Data are presented as n (%) unless otherwise indicated.

    • View popup
    Table 2.

    T Test Results for Two Independent Means to Assess Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) Score Changes Over Time in Patients With Alzheimer Disease

    VariableDecline in MMSE ScoreDecline in MoCA Score
    Sex
     Male2.26 (2.67)2.06 (1.82)
     Female2.25 (2.79)2.43 (1.89)
     T Value0.020.77
     P Value0.490.22
    Race
     White2.27 (2.92)2.43 (1.94)
     Nonwhite (Black, Hispanic)2.92 (2.35)2.30 (1.77)
     T Value0.650.25
     P Value0.260.40
    Marital status
     Married2.31 (2.98)2.29 (1.79)
     Widowed2.01 (2.20)2.83 (1.87)
     T Value0.371.02
     P Value0.360.16
    Age
     <75 years2.88 (3.43)2.18 (2.15)
     ≥75 years2.01 (2.11)2.56 (1.64)
     T Value1.050.78
     P Value0.150.22
    Smoking
     Smoker3.50 (3.20)2.07 (1.72)
     Nonsmoker1.54 (2.07)2.58 (1.96)
     T Value2.531.03
     P Value0.0070.15
    Alcohol
     Alcohol2.96 (3.46)1.98 (1.77)
     No alcohol1.94 (1.73)2.64 (1.89)
     T Value1.321.34
     P Value0.0970.093
    Diabetes mellitus
     With3.36 (3.33)1.85 (1.59)
     Without2.10 (2.60)2.58 (1.97)
     T Value1.341.34
     P Value0.090.09
    Cerebrovascular accident
     With2.48 (1.96)2.50 (1.90)
     Without2.31 (2.87)2.39 (1.88)
     T Value0.140.15
     P Value0.440.44
    Hypothyroidism
     With2.24 (2.04)2.45 (1.41)
     Without2.24 (2.76)2.62 (2.46)
     T Value0.0020.23
     P Value0.500.41
    Major depressive disorder
     With1.61 (1.94)2.22 (1.96)
     Without2.60 (3.01)2.52 (1.84)
     T Value1.160.58
     P Value0.130.28
    • Note: Data other than T and P values are presented as n (%).

PreviousNext
Back to top

In this issue

Ochsner Journal: 22 (2)
Ochsner Journal
Vol. 22, Issue 2
Jun 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Ochsner Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Rates of Cognitive Decline in 100 Patients With Alzheimer Disease
(Your Name) has sent you a message from Ochsner Journal
(Your Name) thought you would like to see the Ochsner Journal web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Rates of Cognitive Decline in 100 Patients With Alzheimer Disease
Monica Miyakawa-Liu, Amy K. Feehan, Shannon Pai, Julia Garcia-Diaz
Ochsner Journal Jun 2022, 22 (2) 129-133; DOI: 10.31486/toj.21.0084

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Rates of Cognitive Decline in 100 Patients With Alzheimer Disease
Monica Miyakawa-Liu, Amy K. Feehan, Shannon Pai, Julia Garcia-Diaz
Ochsner Journal Jun 2022, 22 (2) 129-133; DOI: 10.31486/toj.21.0084
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • INTRODUCTION
    • METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Short-Term Risk of Complications Related to Obstructive Sleep Apnea After Sinonasal Surgery
  • Effect of Statin Potency on Rapid Coronary Intimal Thickening and Rejection in Heart Transplant Recipients
  • Examination of Aeroallergen Sensitization Patterns in Southeastern Louisiana
Show more ORIGINAL RESEARCH

Similar Articles

Keywords

  • Alzheimer disease
  • cognitive dysfunction
  • dementia
  • mental status and dementia tests
  • neuropsychological tests

Our Content

  • Home
  • Current Issue
  • Ahead of Print
  • Archive
  • Featured Contributors
  • Ochsner Journal Blog
  • Archive at PubMed Central

Information & Forms

  • Instructions for Authors
  • Instructions for Reviewers
  • Submission Checklist
  • FAQ
  • License for Publishing-Author Attestation
  • Patient Consent Form
  • Submit a Manuscript

Services & Contacts

  • Permissions
  • Sign up for our electronic table of contents
  • Feedback Form
  • Contact Us

About Us

  • Editorial Board
  • About the Ochsner Journal
  • Ochsner Health
  • University of Queensland-Ochsner Clinical School
  • Alliance of Independent Academic Medical Centers

© 2026 Ochsner Clinic Foundation

Powered by HighWire