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Case ReportCASE REPORTS AND CLINICAL OBSERVATIONS
Open Access

Brain Calcifications Secondary to Idiopathic Hyperthyroidism and Hypoparathyroidism

Bushra Zafar Sayeed, Faiza Zafar Sayeed, Muhammad Nashit and Shaheen Bhatty
Ochsner Journal March 2024, 24 (1) 53-57; DOI: https://doi.org/10.31486/toj.23.0004
Bushra Zafar Sayeed
1Department of Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, Pakistan
MD
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Faiza Zafar Sayeed
1Department of Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, Pakistan
MD
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  • For correspondence: faiza.sayeed@hotmail.com
Muhammad Nashit
1Department of Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, Pakistan
MD
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Shaheen Bhatty
1Department of Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, Pakistan
MBBS, FCPS, PhD
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  • Article
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Article Figures & Data

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    Figure 1.

    Trousseau sign in the right hand.

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    Figure 2.

    Pelvic x-ray in anteroposterior view shows ossification of the iliolumbar, sacrospinous, and sacrotuberous ligaments and the acetabular margins.

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    Figure 3.

    Noncontrast-enhanced computed tomography scan of the (A) left and (B) right cerebral hemispheres showing calcifications in the basal ganglia and thalami.

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    Table.

    Patient's Laboratory Values at Admission

    TestValueReference Range
    Complete blood count
    Hemoglobin, g/dL10.312.1-15.1 (females)
    Hematocrit, %3236-48 (females)
    Mean corpuscular volume, fl8680-100
    White blood cells, μL10,5004,000-11,000
    Platelets, μL387,000150,000-450,000
    Renal function tests
    Blood urea nitrogen, mg/dL256-24
    Creatinine, mg/dL1.30.6-1.1 (females)
    Sodium, mEq/L141135-145
    Potassium, mEq/L3.63.6-5.2
    Chloride, mEq/L9896-106
    Bicarbonate, mEq/L22.322-29
    Calcium, vitamin D, and parathyroid hormone
    Calcium, mg/dL5.28.5-10.2
    Corrected calcium, mg/dL5.8
    Phosphorus, mg/dL72.8-4.5
    Magnesium, mg/dL2.21.7-2.2
    Vitamin D, ng/mL1730-50
    Parathyroid hormone, pg/mL2.0810-55
    Thyroid profile
    Thyroid stimulating hormone, μIU/mL<0.10.4-4.5
    Free T3, pmol/L9.12.0-7.0
    Free T4, ng/dL3.60.9-2.3
    Thrombophilia profile
    Prothrombin time, sec1011-13.5
    Activated partial thromboplastin time, sec2621-35
    International normalized ratio0.90.8-1.1
    Liver function tests
    Total bilirubin, mg/dL0.50.1-1.2
    Alanine transaminase, IU/L427-55
    Aspartate aminotransferase, IU/L258-48
    Alkaline phosphatase, IU/L21044-147
    Gamma-glutamyl transpeptidase, IU/L480-30
    Viral markers
    Hepatitis B surface antigenNegative
    Hepatitis C antibodyNegative
    Autoimmune profile
    Antinuclear antibodiesNegative
    Anti-double stranded DNANegative
    Antimitochondrial antibodiesNegative
    Anti-TPONegative
    Antithyroglobulin antibodyNegative
    Nutritional profile
    Iron, μg/dL7250-150
    Ferritin, μg/L35024-336
    Total iron binding capacity, μg/dL270250-450
    Vitamin B12, ng/L587200-1,100
    Folate, ng/mL106-40
    Other tests
    Total protein, g/dL6.06.0-8.3
    Albumin, g/dL3.53.4-5.4
    Globulin, g/dL2.52.0-3.9
    Albumin/globulin ratio1.51.1-2.5
    Erythrocyte sedimentation rate, mm/h1240-29 (females)
    C-reactive protein, mg/L548-10
    Creatine phosphokinase, U/L1,48030-135 (females)
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Brain Calcifications Secondary to Idiopathic Hyperthyroidism and Hypoparathyroidism
Bushra Zafar Sayeed, Faiza Zafar Sayeed, Muhammad Nashit, Shaheen Bhatty
Ochsner Journal Mar 2024, 24 (1) 53-57; DOI: 10.31486/toj.23.0004

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Brain Calcifications Secondary to Idiopathic Hyperthyroidism and Hypoparathyroidism
Bushra Zafar Sayeed, Faiza Zafar Sayeed, Muhammad Nashit, Shaheen Bhatty
Ochsner Journal Mar 2024, 24 (1) 53-57; DOI: 10.31486/toj.23.0004
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Keywords

  • Calcification–physiologic
  • endocrinology
  • hyperthyroidism
  • hypoparathyroidism

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