Evaluation of the Diagnostic Accuracy of the T2Resistance Panel (Research Use Only) in Patients With Possible Bacterial Bloodstream Infections

REFERENCES

1. 1.↵
   World Health Organization. Global Report on the Epidemiology and Burden of Sepsis: Current Evidence, Identifying Gaps and Future Directions. Published September 9, 2020. Accessed March 2, 2025. who.int/publications/i/item/9789240010789
2. 2.↵
   1. Fabre V,
   2. Carroll KC,
   3. Cosgrove SE

   . Blood culture utilization in the hospital setting: a call for diagnostic stewardship. J Clin Microbiol. 2022;60(3):e0100521. doi: 10.1128/JCM.01005-21

   OpenUrlCrossRefPubMed
3. 3.↵
   1. Nieman AE,
   2. Savelkoul PHM,
   3. Beishuizen A,
   4. et al.

   A prospective multicenter evaluation of direct molecular detection of blood stream infection from a clinical perspective. BMC Infect Dis. 2016;16:314. doi: 10.1186/s12879-016-1646-4

   OpenUrlCrossRefPubMed
4. 4.↵
   1. Sweeney TE,
   2. Liesenfeld O,
   3. May L

   . Diagnosis of bacterial sepsis: why are tests for bacteremia not sufficient? Expert Rev Mol Diagn. 2019;19(11):959-962. doi: 10.1080/14737159.2019.1660644

   OpenUrlCrossRefPubMed
5. 5.↵
   1. Samuel L

   . Direct-from-blood detection of pathogens: a review of technology and challenges. J Clin Microbiol. 2023;61(7):e0023121. doi: 10.1128/jcm.00231-21

   OpenUrlCrossRefPubMed
6. 6.↵
   1. Yee R,
   2. Dien Bard J,
   3. Simner PJ

   . The genotype-to-phenotype dilemma: how should laboratories approach discordant susceptibility results? J Clin Microbiol. 2021;59(6):e00138-20. doi: 10.1128/JCM.00138-20

   OpenUrlAbstract/FREE Full Text
7. 7.↵
   1. Nguyen MH,
   2. Clancy CJ,
   3. Pasculle AW,
   4. et al.

   Performance of the T2Bacteria Panel for diagnosing bloodstream infections: a diagnostic accuracy study. Ann Intern Med. 2019;170(12):845-852. doi: 10.7326/M18-2772

   OpenUrlCrossRefPubMed
8. 8.
   1. De Angelis G,
   2. Posteraro B,
   3. De Carolis E,
   4. et al.

   T2Bacteria magnetic resonance assay for the rapid detection of ESKAPEc pathogens directly in whole blood. J Antimicrob Chemother. 2018;73(suppl_4):iv20-iv26. doi: 10.1093/jac/dky049

   OpenUrlCrossRefPubMed
9. 9.
   1. Drevinek P,
   2. Hurych J,
   3. Antuskova M,
   4. et al.

   Direct detection of ESKAPEc pathogens from whole blood using the T2Bacteria Panel allows early antimicrobial stewardship intervention in patients with sepsis. Microbiologyopen. 2021;10(3):e1210. doi: 10.1002/mbo3.1210

   OpenUrlCrossRefPubMed
10. 10.
    1. Lucignano B,
    2. Cento V,
    3. Agosta M,
    4. et al.

    Effective rapid diagnosis of bacterial and fungal bloodstream infections by T2 magnetic resonance technology in the pediatric population. J Clin Microbiol. 2022;60(10):e0029222. doi: 10.1128/jcm.00292-22

    OpenUrlCrossRefPubMed
11. 11.
    1. Voigt C,
    2. Silbert S,
    3. Widen RH,
    4. et al.

    The T2Bacteria assay is a sensitive and rapid detector of bacteremia that can be initiated in the emergency department and has potential to favorably influence subsequent therapy. J Emerg Med. 2020;58(5):785-796. doi: 10.1016/j.jemermed.2019.11.028

    OpenUrlCrossRefPubMed
12. 12.
    1. Guinea J

    . Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 2014;20 Suppl 6:5-10. doi: 10.1111/1469-0691.12539

    OpenUrlCrossRefPubMed
13. 13.
    1. Clancy CJ,
    2. Nguyen MH

    . T2 magnetic resonance for the diagnosis of bloodstream infections: charting a path forward. J Antimicrob Chemother. 2018;73(suppl_4):iv2-iv5. doi: 10.1093/jac/dky050

    OpenUrlCrossRefPubMed
14. 14.↵
    1. Mylonakis E,
    2. Clancy CJ,
    3. Ostrosky-Zeichner L,
    4. et al.

    T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. Clin Infect Dis. 2015;60(6):892-899. doi: 10.1093/cid/ciu959

    OpenUrlCrossRefPubMed
15. 15.↵
    1. Giannella M,
    2. Pankey GA,
    3. Pascale R,
    4. Miller VM,
    5. Miller LE,
    6. Seitz T

    . Antimicrobial and resource utilization with T2 magnetic resonance for rapid diagnosis of bloodstream infections: systematic review with meta-analysis of controlled studies. Expert Rev Med Devices. 2021;18(5):473-482. doi: 10.1080/17434440.2021.1919508

    OpenUrlCrossRefPubMed
16. 16.↵
    CDC: Antimicrobial Resistance. 2019 Antimicrobial Resistance Threat Report. U.S. Centers for Disease Control and Prevention. Accessed October 7, 2024. cdc.gov/antimicrobial-resistance/data-research/threats/
17. 17.↵
    T2 Biosystems. 2019. T2Resistance® Panel RUO Instructions for Use. T2 Biosystems, Inc., Lexington, MA.
18. 18.↵
    1. De Angelis G,
    2. Paggi R,
    3. Lowery TJ,
    4. et al.

    Direct testing for KPC-mediated carbapenem resistance from blood samples using a T2 magnetic resonance based assay. Antibiotics (Basel). 2021;10(8):950. doi: 10.3390/antibiotics10080950

    OpenUrlCrossRefPubMed
19. 19.↵
    1. Giacobbe DR,
    2. Crea F,
    3. Morici P,
    4. et al.

    T2Bacteria and T2Resistance assays in critically ill patients with sepsis or septic shock: a descriptive experience. Antibiotics (Basel). 2022;11(12):1823. doi: 10.3390/antibiotics11121823

    OpenUrlCrossRefPubMed