Research ArticleArticle

Induced Hypothermia as a Neuroprotectant in Post-Cardiac Arrest

Mohi E. Alkadri and Paul McMullan
Ochsner Journal December 2009, 9 (4) 278-281;

REFERENCES

  1. ↵
    1. Benson D. W.,
    2. Williams G. R. Jr.,
    3. Spencer F. C.,
    4. Yates A. J.
    (1959) The use of hypothermia after cardiac arrest. Anesth Analg 38:423–428, pmid:13798997.
    OpenUrlPubMed
  2. ↵
    (1986) Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. N Engl J Med 314(7):397–403, pmid:2868412.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Jastremski M.,
    2. Sutton-Tyrrell K.,
    3. Vaagenes P.,
    4. Abramson N.,
    5. Heiselman D.,
    6. Safar P.
    (1989) Glucocorticoid treatment does not improve neurological recovery following cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. JAMA 262(24):3427–3430, pmid:2685382.
    OpenUrlCrossRefPubMedWeb of Science
  4. ↵
    1. Bernard S. A.,
    2. Jones B. M.,
    3. Horne M. K.
    (1997) Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med 30(2):146–153, pmid:9250636.
    OpenUrlCrossRefPubMedWeb of Science
    1. Yanagawa Y.,
    2. Ishihara S.,
    3. Norio H.,
    4. et al.
    (1998) Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest. Resuscitation 39(1–2):61–66, pmid:9918449.
    OpenUrlCrossRefPubMedWeb of Science
    1. Nagao K.,
    2. Hayashi N.,
    3. Kanmatsuse K.,
    4. et al.
    (2000) Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital. J Am Coll Cardiol 36(3):776–783, pmid:10987599.
    OpenUrlFREE Full Text
    1. Zeiner A.,
    2. Holzer M.,
    3. Sterz F.,
    4. et al.
    (2000) Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke 31(1):86–94, pmid:10625721.
    OpenUrlAbstract/FREE Full Text
    1. Felberg R. A.,
    2. Krieger D. W.,
    3. Chuang R.,
    4. et al.
    (2001) Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol. Circulation 104(15):1799–1804, pmid:11591617.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Mori K.,
    2. Takeyama Y.,
    3. Itoh Y.,
    4. et al.
    (2000) A multivariate analysis of prognostic factors in survivors of out-of-hospital cardiac arrest with brain hypothermia therapy [abstract]. Crit Care Med 28(12 Suppl.) A168.
    OpenUrl
  10. ↵
    (2002) Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346(8):549–556, pmid:11856793, Erratum in: N Engl J Med. 2002;346(22):1756.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Bernard S. A.,
    2. Gray T. W.,
    3. Buist M. D.,
    4. et al.
    (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346(8):557–563, pmid:11856794.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Nolan J. P.,
    2. Morley P. T.,
    3. Hoek T. L.,
    4. Hickey R. W.
    (2003) Advancement Life Support Task Force of the International Liaison Committee on Resuscitation. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life Support Task Force of the International Liaison Committee on Resuscitation. Resuscitation 57(3):231–235, pmid:12858857.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    1. Neumar R. W.,
    2. Nolan J. P.,
    3. Adrie C.,
    4. et al.
    (2008) Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 118(23):2452–2483, pmid:18948368.
    OpenUrlFREE Full Text
  14. ↵
    1. Eisenburger P.,
    2. Sterz F.,
    3. Holzer M.,
    4. et al.
    (2001) Therapeutic hypothermia after cardiac arrest. Curr Opin Crit Care 7(3):184–188, pmid:11436525.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Cole S. L.,
    2. Corday E.
    (1956) Four-minute limit for cardiac resuscitation. J Am Med Assoc 161(15):1454–1458, pmid:13345605.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Small D. L.,
    2. Morley P.,
    3. Buchan A. M.
    (1999) Biology of ischemic cerebral cell death. Prog Cardiovasc Dis 42(3):185–207, pmid:10598920.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Siesjö B. K.,
    2. Bengtsson F.,
    3. Grampp W.,
    4. Theander S.
    (1989) Calcium, excitotoxins, and neuronal death in the brain. Ann N Y Acad Sci 568:234–251, pmid:2576507.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Illievich U. M.,
    2. Zornow M. H.,
    3. Choi K. T.,
    4. Scheller M. S.,
    5. Strnat M. A.
    (1994) Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia. Anesth Analg 78(5):905–911, pmid:8160988.
    OpenUrlPubMedWeb of Science
  19. ↵
    1. Ning X. H.,
    2. Chen S. H.,
    3. Xu C. S.,
    4. et al.
    (2002) Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol 92(5):2200–2207, pmid:11960975.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    1. Xu L.,
    2. Yenari M. A.,
    3. Steinberg G. K.,
    4. Giffard R. G.
    (2002) Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab 22(1):21–28, pmid:11807390.
    OpenUrlCrossRefPubMed
    1. Povlishock J. T.,
    2. Buki A.,
    3. Koiziumi H.,
    4. Stone J.,
    5. Okonkwo D. O.
    (1999) Initiating mechanisms involved in the pathobiology of traumatically induced axonal injury and interventions targeted at blunting their progression. Acta Neurochir Suppl 73:15–20, pmid:10494336.
    OpenUrlPubMed
  22. ↵
    1. Adachi M.,
    2. Sohma O.,
    3. Tsuneishi S.,
    4. Takada S.,
    5. Nakamura H.
    (2001) Combination effect of systemic hypothermia and caspase inhibitor administration against hypoxic-ischemic brain damage in neonatal rats. Pediatr Res 50(5):590–595, pmid:11641453.
    OpenUrlCrossRefPubMedWeb of Science
  23. ↵
    1. Otis A. B.,
    2. Jude J.
    (1957) Effect of body temperature on pulmonary gas exchange. Am J Physiol 188(2):355–359, pmid:13411215.
    OpenUrlPubMedWeb of Science
  24. ↵
    1. Orlowski J. P.,
    2. Erenberg G.,
    3. Lueders H.,
    4. Cruse R. P.
    (1984) Hypothermia and barbiturate coma for refractory status epilepticus. Crit Care Med 12(4):367–372, pmid:6705545.
    OpenUrlCrossRefPubMedWeb of Science
  25. ↵
    1. Globus M. Y.,
    2. Alonso O.,
    3. Dietrich W. D.,
    4. Busto R.,
    5. Ginsberg M. D.
    (1995) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem 65(4):1704–1711, pmid:7561868.
    OpenUrlPubMedWeb of Science
  26. ↵
    1. Globus M. Y.,
    2. Busto R.,
    3. Lin B.,
    4. Schnippering H.,
    5. Ginsberg M. D.
    (1995) Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 65(3):1250–1256, pmid:7643104.
    OpenUrlPubMedWeb of Science
  27. ↵
    1. Busto R.,
    2. Globus M. Y.,
    3. Dietrich W. D.,
    4. Martinez E.,
    5. Valdés I.,
    6. Ginsberg M. D.
    (1989) Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20(7):904–910, pmid:2568705.
    OpenUrlAbstract/FREE Full Text
    1. Dempsey R. J.,
    2. Combs D. J.,
    3. Maley M. E.,
    4. Cowen D. E.,
    5. Roy M. W.,
    6. Donaldson D. L.
    (1987) Moderate hypothermia reduces postischemic edema development and leukotriene production. Neurosurgery 21(2):177–181, pmid:2821445.
    OpenUrlCrossRefPubMedWeb of Science
    1. Kimura A.,
    2. Sakurada S.,
    3. Ohkuni H.,
    4. Todome Y.,
    5. Kurata K.
    (2002) Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Crit Care Med 30(7):1499–1502, pmid:12130969.
    OpenUrlCrossRefPubMedWeb of Science
    1. Aibiki M.,
    2. Maekawa S.,
    3. Ogura S.,
    4. Kinoshita Y.,
    5. Kawai N.,
    6. Yokono S.
    (1999) Effect of moderate hypothermia on systemic and internal jugular plasma IL-6 levels after traumatic brain injury in humans. J Neurotrauma 16(3):225–232, pmid:10195470.
    OpenUrlCrossRefPubMedWeb of Science
  31. ↵
    1. Siesjö B. K.
    (1992) Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 77(2):169–184, pmid:1625004.
    OpenUrlCrossRefPubMedWeb of Science
  32. ↵
    1. Merchant R. M.,
    2. Abella B. S.,
    3. Peberdy M. A.,
    4. et al.
    (2006) Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blankets. Crit Care Med 34(12 Suppl):S490–S494, pmid:17114983.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Hachimi-Idrissi S.,
    2. Corne L.,
    3. Ebinger G.,
    4. Michotte Y.,
    5. Huyghens L.
    (2001) Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation 51(3):275–281, pmid:11738778.
    OpenUrlCrossRefPubMedWeb of Science
  34. ↵
    1. Mori K.,
    2. Saito J.,
    3. Kurata Y.,
    4. et al.
    (2001) Rapid development of brain hypothermia using femoral-carotid bypass. Acad Emerg Med 8(4):303–308, pmid:11282663.
    OpenUrlPubMedWeb of Science
  35. ↵
    1. Arrich J.
    (2007) European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 35(4):1041–1047, pmid:17334257.
    OpenUrlCrossRefPubMedWeb of Science
  36. ↵
    1. Haugk M.,
    2. Sterz F.,
    3. Grassberger M.,
    4. et al.
    (2007) Feasibility and efficacy of a new non-invasive surface cooling device in post-resuscitation intensive care medicine. Resuscitation 75(1):76–81, pmid:17462808.
    OpenUrlCrossRefPubMedWeb of Science
  37. ↵
    1. Holzer M.,
    2. Janata A.,
    3. Haugk M.,
    4. Krizanac D.,
    5. Sterz F.
    (2008) Efficacy and safety of a novel rapid non-invasive surface-cooling device for induction of therapeutic hypothermia in patients after cardiac arrest [abstract]. Resuscitation 77(1 Suppl):S29.
    OpenUrl
  38. ↵
    1. Knafelj R.,
    2. Radsel P.,
    3. Ploj T.,
    4. Noc M.
    (2007) Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction. Resuscitation 74(2):227–234, pmid:17383070.
    OpenUrlCrossRefPubMedWeb of Science
  39. ↵
    1. Abella B. S.
    (2008) Hypothermia and coronary intervention after cardiac arrest: thawing a cool relationship? Crit Care Med 36(6):1967–1968, pmid:18520656.
    OpenUrlPubMed
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