Article Figures & Data
Figures
- Figure 1.
(A) Endoscopic ultrasound showed a well-circumscribed cystic lesion measuring 4.0 × 2.8 cm in the uncinate process and a mural nodule (asterisk) measuring 2.6 × 2.2 cm. (B) A neoplastic thrombus (arrow) was partially obstructing the superior mesenteric vein. (C) The mural nodule was punctured by endoscopic ultrasound-guided biopsy (arrowhead).
- Figure 2.
(A) Histologic findings of pancreatic metastasis from papillary thyroid carcinoma demonstrated a tumor consisting of cuboidal cells with irregular membrane, vacuolated cytoplasm, nuclear grooves, oval nuclei with granular chromatin, and no mitotic activity. A papillary arrangement and fibrovascular cores with pseudoinclusions were detected in the pancreatic tissue (hematoxylin and eosin stain, magnification ×400). Neoplastic cells showed intense immunoreactivity for (B) thyroglobulin (magnification ×200), (C) thyroid transcription factor 1 (magnification ×100), and (D) cytokeratin 7 (magnification ×100). Thyroglobulin and cytokeratin 7 were positive for membranous and cytoplasmic immunoreactivity. Thyroid transcription factor 1 indicates nuclear positivity.
- Figure 3.
Contrast-enhanced axial abdominal computed tomography scan showed a 4.9 × 3.5 × 2.8-cm pancreatic cystic lesion in the uncinate process with a mural nodule in the cystic lumen (arrow).
Tables
- Table 1.
Patient and Disease Details From Reports of Primary Papillary Thyroid Carcinomas With Pancreatic Metastasis
Study Age, years Sex Histology TNM Classification Stage Thyroidectomy RAI Locoregional Recurrence Metastases Before Pancreatic Metastasis Sugimura et al, 19914 32 F Classic NR NR Total NR NR NR Jobran et al, 20005 52 M Tall cell T4aN1M0 I Total Yes Yes No Meyer and Behrend, 20066 62 M Classic T4aN0M0 III Total Yes Yes Lung, adrenal Siddiqui et al, 20067 62 M Tall cell T4aN1bM0 III Total Yes No Lung Angeles-Angeles et al, 20098 72 M Classic T4bNxM1 IVB None Yes No No Chen and Brainard, 20109 77 M Classic T3N1M0 II Total Yes Yes No Borschitz et al, 201010 34 F Follicular T3N1aM0 I Total NR Yes No 46 M Classic T3N1M0 I Total Yes Yes No Alzahrani et al, 201211 47 M Classic T4aN1bM0 I Total Yes Yes Lung Olson et al, 201312 59 F Classic NR NR NR NR NR No Tunio et al, 201313 60 M Follicular T2N1M0 II Total Yes No No Li et al, 201414 55 M Classic NR NR Partial NR Yes No Davidson et al, 201716 82 F Tall cell T3N1bM0 II Total Yes Yes No Murakami et al, 201817 66 F Classic T4aN1bM0 III Total NR Yes No Cho et al, 201915 71 M Classic NR NR Total Yes Yes Lung Yang et al, 201919 48 M Classic T4aN1M1 II Total Yes No No Tramontin et al, 202018 67 M Classic T4aN1bM0 III Total Yes Yes No Ren et al, 202020 47 M Classic T4aN0M1 II Total Yes No No Rossi et al, 202021 45 M Classic NR NR NR NR Yes Lung, brain Uslar et al, 202022 80 M Tall cell T4aN1M1 IVB Total Yes No No Yoon et al, 202023 71 M Classic T3NxM0 II NR NR NR NR 61 M Classic T3N1bM0 II NR NR NR NR Stein et al, 202024 46 M Tall cell T4aN1M0 I Total Yes Yes No Wong et al, 202125 68 M Classic NR NR NR Yes NR NR Warda et al, 202226 46 M Tall cell T4aN1M0 I Total Yes Yes No Song et al, 202327 51 M Classic T3N1bM0 I Total Yes Yes No Ahmadian et al, 202428 66 M Classic NR NR Total Yes NR NR Present case 79 F Classic T2N1M0 II Total Yes No No F, female; M, male; NR, not reported; RAI: radioactive iodine ablation; TNM, tumor-node-metastasis.
- Table 2.
Diagnostic, Treatment, and Outcome Details of Pancreatic Metastases From Reports of Patients With Papillary Thyroid Carcinomas
Study Time After PTC Diagnosis, years Clinical Features Imaging Iodine- Avid Local Size, cm Solid/Cyst Sampling Other Metastases at Diagnosis of PM Treatment Follow-up, months Outcome Sugimura et al, 19914 7 Jaundice, itching CT, US NR Head 3 NR NR No Surgery (PD) NR NR Jobran et al, 20005 1 Abdominal pain MRI No Head 3.5/2.5 Cyst CT-FNA Lung, vertebra Surgery (PD), carboplatin and doxorubicin 0.5 Died Meyer and Behrend, 20066 5 Anemia, duodenal bleeding ulcer CT No Head NR Cyst Endoscopic biopsy of duodenal ulcer Lung, liver, kidney Surgery (DP) 54 Died Siddiqui et al, 20067 7 Abdominal pain CT, PET No Head 1.5 Solid EUS-TA Lung Surgery (PD) 24 Alive Angeles-Angeles et al, 20098 Synchronous Abdominal pain CT NR Tail 8.5 Solid Upfront surgery Brain, vertebra Surgery (DP) 8 Alive Chen and Brainard, 20109 5 Pancreatitis EUS NR Neck 3 Solid EUS-TA NR NR NR NR Borschitz et al, 201010 10 NR CT, PET, MRI No Head 4 Solid Upfront surgery No Surgery (DP) 7 Alive 15 NR CT, PET No Body NR Solid Upfront surgery Lung, bone, skin Surgery (enucleation), RAI 36 Died Alzahrani et al, 201211 8 Asymptomatic PET, MRI No UP 1.7 Solid EUS-TA Lung, vertebra, liver, peritoneum Sorafenib 20 Died Olson et al, 201312 Synchronous NR NR NR NR NR NR EUS-TA NR NR NR NR Tunio et al, 201313 7 Abdominal pain CT, MRI No Neck 1.8 Solid CT-FNA Lung Surgery (PD), sorafenib 36 Alive Li et al, 201414 11 Asymptomatic CT, PET NR Body/tail 6.2 Solid Upfront surgery No Surgery (DP) 5 Died Davidson et al, 201716 2 Asymptomatic CT, PET NR Body 1.1 Solid EUS-TA No Surveillance 6 Alive Murakami et al, 201817 14 Asymptomatic CT, PET, MRI NR Body 3 Solid EUS-TA Lung Surgery (DP), paclitaxel 11 Died Cho et al, 201915 10 Asymptomatic PET, MRI NR Body 1.4 Solid EUS-TA Lung Surveillance 1 Alive Yang et al, 201919 Synchronous Abdominal pain US NR Body 2.5 Solid Upfront surgery Lung, liver, kidney, parotid, skin, skeletal muscle, bone Surgery (DP), lenvatinib 18 Alive Tramontin et al, 202018 6 Jaundice, nausea, weight loss PET NR Head 3.5 Solid EUS-TA No Surgery (PD), sorafenib 7 Alive Ren et al, 202020 Synchronous Abdominal pain CT, US NR Body 4 Solid Upfront surgery Liver, diaphragm, parotid Surgery (DP), RAI 5 Alive Rossi et al, 202021 15 Pancreatitis CT, MRI NR Head 2 Solid EUS-TA No Surgery (PD) NR NR Uslar et al, 202022 Synchronous Jaundice CT, PET, MRI, NR Head 3.6 Solid EUS-TA Lung, brain, skeletal muscle RAI and RT 12 Alive Yoon et al, 202023 NR NR CT, PET NR Head 6 Solid EUS-TA Lung Lenvatinib 36 Alive NR Asymptomatic NR NR Body/tail 7 NR CT-FNA Lung, bone Lenvatinib 23 Alive Stein et al, 202024 3 NR PET No Head 3 Solid Upfront surgery Vertebra Surgery (PD), lenvatinib 6 Alive Wong et al, 202125 7 NR PET Yes Body/tail NR Solid NR NR RAI NR NR Warda et al, 202226 3 NR PET NR Head 3 NR Upfront surgery No Surgery (PD), lenvatinib NR Alive Song et al, 202327 6 Diabetes CT, PET, MRI NR Tail 5.6 Cyst Upfront surgery No Surgery (DP) 36 Alive Ahmadian et al, 202428 5 Asymptomatica CT, PET NR Tail NR Solid EUS-TA Liver, adrenal, peritoneum NR NR NR Present case 11 Asymptomatic CT, PET No UP 4 Cyst EUS-TA Liver, vertebra, retroperitoneal lymph node RAI, RT 23 Died ↵aThe patient had pneumonia but no tumor-related symptoms.
Note: All pancreatic metastases were solitary lesions, except for a single patient with 2 lesions in the pancreatic head.5
CT, computed tomography; CT-FNA, computed tomography-guided fine needle aspiration; DP, distal pancreatectomy; EUS, endoscopic ultrasound; EUS-TA, endoscopic ultrasound-guided tissue acquisition; MRI, magnetic resonance imaging; NR, not reported; PD, pancreaticoduodenectomy; PET, positron emission tomography; PM, pancreatic metastasis; PTC, papillary thyroid carcinoma; RAI, radioactive iodine ablation; RT, radiotherapy; UP, uncinate process; US, ultrasound.
- Table 3.
Immunohistochemistry and Genetic Findings of Pancreatic Metastases From Reports of Patients With Papillary Thyroid Carcinomas
Study Thyroglobulin Thyroid Transcription Factor 1 BRAFV600E Mutation Sugimura et al, 19914 NR NR NR Jobran et al, 20005 Positive NR NR Meyer and Behrend, 20066 Positive NR NR Siddiqui et al, 20067 Positive Positive NR Angeles-Angeles et al, 20098 Positive Positive NR Chen and Brainard, 20109 Positive NR NR Borschitz et al, 201010 Positive NR Negative Positive NR Positive Alzahrani et al, 201211 Positive Positive Positive Olson et al, 201312 NR NR NR Tunio et al, 201313 NR NR Positive Li et al, 201414 Positive Positive NR Davidson et al, 201716 Positive Positive Positive Murakami et al, 201817 Positive Positive Positive Cho et al, 201915 NR Positive NR Yang et al, 201919 Positive Positive Positive Tramontin et al, 202018 NR Positive NR Ren et al, 202020 Positive Positive Positive Rossi et al, 202021 NR Positive NR Uslar et al, 202022 Positive Positive Positive Yoon et al, 202023 NR NR Negative NR NR NR Stein et al, 202024 Positive Positive NR Wong et al, 202125 NR NR NR Warda et al, 202226 Positive Positive Positive Song et al, 202327 Positive Positive Positive Ahmadian et al, 202428 NR Positive Negative Present case Positive Positive NR NR, not reported.
In this issue
Jump to section
Cited By...
- No citing articles found.