PT - JOURNAL ARTICLE AU - Alkadri, Mohi E. AU - McMullan, Paul TI - Induced Hypothermia as a Neuroprotectant in Post-Cardiac Arrest DP - 2009 Dec 21 TA - Ochsner Journal PG - 278--281 VI - 9 IP - 4 4099 - http://www.ochsnerjournal.org/content/9/4/278.short 4100 - http://www.ochsnerjournal.org/content/9/4/278.full SO - Ochsner J2009 Dec 21; 9 AB - Survivors of out-of-hospital cardiac arrest frequently suffer devastating effects from anoxic brain injury. Therapeutic hypothermia is the first therapy to show benefit in improving survival as well as limiting neurologic injury. We review the data supporting the use of therapeutic hypothermia in this patient population, the pathophysiologic basis of its neuroprotectant effects, the methods of hypothermic induction, and the clinical application.