PT  - JOURNAL ARTICLE
AU  - Robert A. Felberg
AU  - Andrew Naidech
TI  - The Five Ps of Acute Ischemic Stroke Treatment: Parenchyma, Pipes, Perfusion, Penumbra, and Prevention of Complications
DP  - 2003 Dec 21
TA  - Ochsner Journal
PG  - 5--11
VI  - 5
IP  - 1
4099  - http://www.ochsnerjournal.org/content/5/1/5.short
4100  - http://www.ochsnerjournal.org/content/5/1/5.full
SO  - Ochsner J2003 Dec 21; 5
AB  - Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke treatment is approached. Acute ischemic stroke is a challenging and heterogeneous disease, and treatment must be based on an understanding of the underlying pathophysiology of ischemia. Interventions are designed to improve neuronal salvage and outcome. The underlying tenets of stroke therapy focus on the brain parenchyma, arterial flow (pipes), perfusion, the ischemic milieu or penumbra, and prevention of complications. This article focuses on the practical issues of ischemic stroke care with a brief review of supporting literature.