PT - JOURNAL ARTICLE AU - Khout, Hazem AU - Richardson, Catherine AU - Toghyan, Hamid AU - Fasih, Tarannum TI - The Role of Combined Assessment in Preoperative Axillary Staging DP - 2013 Dec 21 TA - Ochsner Journal PG - 489--494 VI - 13 IP - 4 4099 - http://www.ochsnerjournal.org/content/13/4/489.short 4100 - http://www.ochsnerjournal.org/content/13/4/489.full SO - Ochsner J2013 Dec 21; 13 AB - Background Axillary lymph node status is the most significant single prognostic factor in breast cancer, and preoperative axillary staging is essential in determining lymph node status. Axillary ultrasound scan (AUS) is the gold standard modality in preoperative staging. However, triple assessment—including clinical examination and radiological assessment with fine needle aspiration (FNA) with or without core biopsy—ensures high sensitivity.Methods Our study included 219 women diagnosed with invasive breast cancer between 2009 and 2010. All patients underwent a preoperative staging AUS that was graded from normal (U1) to malignant (U5). All patients with ultrasound scans graded U3 (indeterminate) and above underwent FNA that was graded from C1 (inadequate for diagnosis) to C5 (malignant). Patients diagnosed preoperatively with metastatic lymph nodes were offered axillary lymph node clearance. The rest of the patients were offered sentinel lymph node biopsy.Results The 219 women were diagnosed with 228 invasive breast cancers. The mean age was 60 years (range 29-90 years). The final histology report showed metastatic axillary lymph nodes in 49 (21.5%) cases. Of these 49 cases, 22 were diagnosed preoperatively with metastatic axillary lymph node and were elected for axillary lymph node clearance, and 27 were elected for sentinel lymph node biopsy that revealed metastatic lymph nodes. AUS showed abnormal (U3/U4/U5) axillary lymph nodes in 30 of 49 (61.2%) cancer cases with an overall accuracy of 91.6%.Conclusion Combined triple assessment increases the sensitivity, negative predictive value, and overall accuracy of preoperative staging of the axilla.