RT Journal Article SR Electronic T1 Pulsed Doppler in Simulated Compartment Syndrome: A Pilot Study to Record Hemodynamic Compromise JF Ochsner Journal JO Ochsner J FD O. P. Jindal Global University SP 500 OP 506 VO 13 IS 4 A1 Santiago Mc Loughlin A1 Mario Jorge Mc Loughlin A1 Francisco Mateu YR 2013 UL http://www.ochsnerjournal.org/content/13/4/500.abstract AB Background Acute compartment syndrome occurs when the tissue pressure within a closed muscle compartment exceeds the perfusion pressure. We observed diastolic retrograde arterial flow (DRAF) in 2 patients in the arteries proximal to compartment syndromes in injured limbs. We hypothesized that DRAF may represent an early sign of compartment pressure increments.Methods We mimicked compartment syndrome by using a cuff to produce external compression of the forearm at increasing pressures. We correlated the applied pressure with brachial artery blood flow, velocities, and retrograde flow. We studied the brachial artery at baseline, at external compression of 40 mmHg applied to the forearm, at forearm compression equal to the patient's diastolic blood pressure (DBP), and at forearm compression equal to the patient's mean arterial pressure (MAP). Evaluations included Doppler velocities and DRAF percentage (%). Using a ROC analysis, we selected a DRAF (%) cutoff value for the identification of patients with an applied external pressure equal to or greater than their DBP and calculated its sensitivity and specificity.Results Compared with baseline, DRAF (%) was increased at 40 mmHg (P<0.05), at DBP (P<0.05), and at MAP (P<0.05). DRAF (%) was strongly correlated with applied external pressure (r=0.92, r2=0.85). DRAF 40% presented a 100% sensitivity and a 93% specificity for identifying a compression equal to or greater than the patient's DBP.Conclusion DRAF (%) strongly correlates with the degree of external pressure applied to the brachial artery, suggesting it may represent a useful tool in the detection and evaluation of compartment syndrome.