PT  - JOURNAL ARTICLE
AU  - Souzdalnitski, Dmitri
AU  - Chang, Anita Kumar
AU  - Guirguis, Maged
TI  - Chorea in a Chronic Pain Patient Using Gabapentin
DP  - 2014 Jun 20
TA  - Ochsner Journal
PG  - 276--278
VI  - 14
IP  - 2
4099  - http://www.ochsnerjournal.org/content/14/2/276.short
4100  - http://www.ochsnerjournal.org/content/14/2/276.full
SO  - Ochsner J2014 Jun 20; 14
AB  - Background Gabapentin increasingly is being used to treat chronic pain in addition to seizures, anxiety, and bipolar disorder. Chorea has been reported as a potential side effect of gabapentin.Case Report We report the case of a patient with chronic low back pain who was treated with a host of modalities, including gabapentin. After she increased her dose of gabapentin, she developed chorea of the upper extremities, neck, and head. With cessation of gabapentin, the bulk of her symptoms resolved within 24 hours, and symptoms completely resolved in the following months.Conclusions Chorea is thought to appear when the basal ganglia are deregulated. Gabapentin interferes with gamma-aminobutyric acid, the primary inhibitory neurotransmitter in the motor pathway. Chorea associated with gabapentin has been reported in several case studies, but not at a dose as low as the patient took in this case.