TY - JOUR T1 - Calcific Uremic Arteriolopathy in End Stage Renal Disease: Pathophysiology and Management JF - Ochsner Journal JO - Ochsner J SP - 380 LP - 385 VL - 14 IS - 3 AU - Preethi Yerram AU - Kunal Chaudhary Y1 - 2014/09/21 UR - http://www.ochsnerjournal.org/content/14/3/380.abstract N2 - Background: Calcific uremic arteriolopathy (CUA), a debilitating condition with high morbidity and mortality, is most commonly seen in patients with kidney disease. The pathophysiology of CUA is multifactorial, leading to a disruption in the balance between factors that promote and those that inhibit calcification, although the exact pathophysiological mechanisms of CUA remain to be elucidated.Methods: This review provides an overview of the pathophysiology, clinical presentation and diagnosis, and treatment of CUA.Results: Diagnosis of CUA requires a high degree of suspicion; skin biopsy with histological examination remains the gold standard to confirm the diagnosis. Treatment of CUA requires a multidisciplinary approach.Conclusion: With a high degree of clinical suspicion and early diagnosis, an aggressive multifactorial treatment approach involving optimal wound management, minimization/avoidance of risk factors and precipitating causes, and correction of calcium-phosphorus abnormalities can significantly improve patient outcomes. ER -