RT Journal Article SR Electronic T1 Early Precursor of Mixed Endocrine-Exocrine Tumors of the Gastrointestinal Tract: Histologic and Molecular Correlations JF Ochsner Journal JO Ochsner J FD O. P. Jindal Global University SP 97 OP 101 VO 15 IS 1 A1 Fateh Bazerbachi A1 Taher R. Kermanshahi A1 Carmela Monteiro YR 2015 UL http://www.ochsnerjournal.org/content/15/1/97.abstract AB Background Mixed endocrine-exocrine tumors display histologic features of endocrine and glandular differentiation. Unlike in collision tumors, the two components are thought to arise from a monoclonal precursor. Evidence from molecular testing supports the monoclonal theory and suggests that the exocrine component may give rise to the endocrine component but not vice versa.Case Report We report a case of an adenomatous polyp in the large intestine that had groups of endocrine cells arising from the crypt bases of the adenomatous (exocrine) epithelium. To our knowledge, ours is only the second report of an adenomatous polyp in which groups of microcarcinoid endocrine cells were recognized. The histologic findings in our case correlate with the molecular findings described in mixed endocrine-exocrine tumors.Conclusion Our description may represent the primordial stage of a mixed endocrine-exocrine neoplasm.