PT - JOURNAL ARTICLE AU - Rashed, Ahmed AU - Shokr, Mohamed AU - Subahi, Ahmed AU - Siddiqui, Fayez AU - Alkatib, Aziz AU - Afonso, Luis TI - Reverse Takotsubo Cardiomyopathy in a Patient With Prior Apical Takotsubo Cardiomyopathy: Challenging the Beta Receptor Gradient Theory AID - 10.31486/toj.18.0027 DP - 2019 Sep 21 TA - Ochsner Journal PG - 256--259 VI - 19 IP - 3 4099 - http://www.ochsnerjournal.org/content/19/3/256.short 4100 - http://www.ochsnerjournal.org/content/19/3/256.full SO - Ochsner J2019 Sep 21; 19 AB - Background: Classic Takotsubo cardiomyopathy has been described as transient apical dyskinesia following major stress that is believed to be related to catecholamine surges. Atypical variants have been described, including the rarer reverse Takotsubo cardiomyopathy. Discrepant gradients of the beta-2 adrenoceptors are thought to determine the different anatomic variants.Case Report: A 43-year-old female presented with chest pain and a mild troponin elevation. Echocardiography and coronary angiography were consistent with stress-induced apical Takotsubo cardiomyopathy. Eight months later, the patient was admitted with a similar presentation; however, workup revealed stress-induced reverse Takotsubo cardiomyopathy.Conclusion: Recurrent Takotsubo cardiomyopathy involving different anatomic regions of the left ventricle is a rare phenomenon yet appears to be similar to typical Takotsubo cardiomyopathy in presentation and hospital course. Chronic therapy with beta blockers and angiotensin-converting enzyme inhibitors did not prevent a recurrence in this patient, suggesting that optimum treatment needs to be determined. Takotsubo cardiomyopathy affecting different myocardial segments may recur in the same patient, implying that the adrenoceptor distribution theory needs further refinement.