PT - JOURNAL ARTICLE AU - Broughton, Kirbie AU - Clark, Allison G. AU - Ray, Adrienne P. TI - Nitrous Oxide for Labor Analgesia: What We Know to Date AID - 10.31486/toj.19.0102 DP - 2020 Dec 21 TA - Ochsner Journal PG - 419--421 VI - 20 IP - 4 4099 - http://www.ochsnerjournal.org/content/20/4/419.short 4100 - http://www.ochsnerjournal.org/content/20/4/419.full SO - Ochsner J2020 Dec 21; 20 AB - Background: Although nitrous oxide (N2O) has been used since the 1880s for labor analgesia, its popularity has only recently increased in the United States. In 2011, only 3 centers in the country offered N2O, but as of 2020, several hundred labor units have adopted its use.Methods: We reviewed the literature and summarize the mechanism of action, clinical uses, and efficacy of N2O for labor analgesia, as well as patient satisfaction related to its use.Results: N2O has several proposed mechanisms of action that make it a viable option for all 3 stages of labor and postpartum procedures. N2O has been shown to be a safe option for both mom and baby during labor and delivery. Studies support N2O as an analgesic for laboring. Even though 40% to 60% of women who use N2O convert to a labor epidural analgesia, satisfaction surveys indicate that analgesia is not the only factor contributing to the use of N2O during labor.Conclusion: The use of N2O has increased in labor and delivery units across the United States since 2011. Despite inferior analgesic properties compared to epidural analgesia, N2O offers a safe alternative for many parturients who want a greater sense of control and mobility.