PT  - JOURNAL ARTICLE
AU  - Laurephile Desrosiers
AU  - Leise R. Knoepp
TI  - Botulinum Toxin A: A Review of Potential Uses in Treatment of Female Urogenital and Pelvic Floor Disorders
AID  - 10.31486/toj.19.0076
DP  - 2020 Dec 21
TA  - Ochsner Journal
PG  - 400--409
VI  - 20
IP  - 4
4099  - http://www.ochsnerjournal.org/content/20/4/400.short
4100  - http://www.ochsnerjournal.org/content/20/4/400.full
SO  - Ochsner J2020 Dec 21; 20
AB  - Background: Botulinum toxin is an injectable neuromodulator that inhibits transmission between peripheral nerve endings and muscle fibers, resulting in muscle paralysis. Botulinum toxin type A is the most common form of botulinum toxin used in clinical practice.Methods: In this review, we examine the mechanism of action, formulations, common clinical use in the genital-urinary tract, and potential clinical use in pelvic floor disorders of botulinum toxin type A.Results: Several aspects of botulinum toxin A make it a favorable therapeutic tool, including its accessibility, its longevity, and its impermanence and reversibility of resultant chemodenervation in a relatively short and safe manner. Although botulinum toxin A has well-established efficacy in treating refractory overactive bladder and neurogenic detrusor overactivity, its use in pelvic floor disorders is still in its infancy.Conclusion: The efficacy of botulinum toxin A for treating pelvic pain, voiding dysfunction, muscle pain and dysfunction, and certain colorectal-related pain issues shows promise but requires additional rigorous evaluation.