RT Journal Article
SR Electronic
T1 Pelvic Organ Prolapse: A Review of In Vitro Testing of Pelvic Support Mechanisms
JF Ochsner Journal
JO Ochsner J
FD O. P. Jindal Global University
SP 410
OP 418
DO 10.31486/toj.19.0089
VO 20
IS 4
A1 Cassandra K. Conway
A1 Shelby E. White
A1 Rachel Russell
A1 Claire Sentilles
A1 Gabrielle L. Clark-Patterson
A1 Kristin S. Miller
A1 Laurephile Desrosiers
A1 Leise R. Knoepp
YR 2020
UL http://www.ochsnerjournal.org/content/20/4/410.abstract
AB Background: Pelvic organ prolapse (POP) affects a significant portion of the female population, impacting quality of life and often requiring intervention. The exact cause of prolapse is unknown.Methods: We review some of the current research that focuses on defining the elements involved in POP, with a focus on in vitro testing.Results: Treatment for POP, ranging from physical therapy or pessary use to more invasive surgery, has varying success rates. This variation is, in part, because the pathophysiology of pelvic floor support—and thus dysfunction—is incompletely understood, particularly regarding the structural components and biomechanical properties of tissue. However, researchers are working to identify and quantify the structural and functional dysfunction that may lead to the development of this condition.Conclusion: Given the limited understanding of prolapse development, more research is needed to quantify the microstructure of the pelvic organs and pelvic support structures, with and without prolapse. Identifying biomechanical properties in multiaxial configurations will improve our understanding of pelvic tissue support, as well as our ability to establish predictive models and improve clinical treatment strategies.