TY - JOUR T1 - Perioperative Efficiency of Sugammadex Following Laparoscopic Cholecystectomy in Clinical Practice JF - Ochsner Journal JO - Ochsner J DO - 10.31486/toj.22.0064 AU - Christian Lee AU - Hana Ahsan AU - Hoon Chae AU - Danielle M. Esnard AU - David Broussard AU - Stuart Hart AU - Alex Allain III AU - Brittany Bond AU - Eric Busch AU - Preya Jhita AU - Melissa Matte AU - Robin Stedman AU - Jacob Lessing AU - Joseph Koveleskie AU - Bobby D. Nossaman Y1 - 2022/12/21 UR - http://www.ochsnerjournal.org/content/early/2022/10/24/toj.22.0064.abstract N2 - Background: Studies have proposed that the routine use of the modified gamma-cyclodextrin, sugammadex, could provide perioperative time savings. However, these investigations have been limited to small group analyses. The purpose of this study was to test the effectiveness of sugammadex on perioperative times when compared to neostigmine under general clinical practice conditions following rocuronium-induced neuromuscular blockade for laparoscopic cholecystectomy.Methods: Following institutional review board approval, data from 1,611 consecutive surgical records for laparoscopic cholecystectomy were reviewed. Patient characteristics, type of primary neuromuscular blocking reversal agent, operating room (OR) discharge times, and postanesthesia care unit (PACU) recovery times were the measures of interest. Equivalence testing was used to determine the between-group differences of the reversal agents in the two perioperative time periods of interest.Results: OR discharge times averaged 10.9 (95% CI, 10-11.8) minutes for patients administered sugammadex and 8.9 (95% CI, 8.2-9.7) minutes for patients administered neostigmine. PACU recovery times averaged 77.6 (95% CI, 74.1-81.1) minutes for sugammadex and 68.6 (95% CI, 65.9-71.3) minutes for neostigmine. Equivalence testing demonstrated no improvement in the two perioperative times with sugammadex.Conclusion: These results suggest no perioperative time savings with sugammadex when compared to neostigmine following laparoscopic cholecystectomy under general clinical practice conditions. ER -