RT Journal Article SR Electronic T1 Perioperative Efficiency of Sugammadex Following Laparoscopic Cholecystectomy in Clinical Practice JF Ochsner Journal JO Ochsner J FD O. P. Jindal Global University DO 10.31486/toj.22.0064 A1 Christian Lee A1 Hana Ahsan A1 Hoon Chae A1 Danielle M. Esnard A1 David Broussard A1 Stuart Hart A1 Alex Allain III A1 Brittany Bond A1 Eric Busch A1 Preya Jhita A1 Melissa Matte A1 Robin Stedman A1 Jacob Lessing A1 Joseph Koveleskie A1 Bobby D. Nossaman YR 2022 UL http://www.ochsnerjournal.org/content/early/2022/10/24/toj.22.0064.abstract AB Background: Studies have proposed that the routine use of the modified gamma-cyclodextrin, sugammadex, could provide perioperative time savings. However, these investigations have been limited to small group analyses. The purpose of this study was to test the effectiveness of sugammadex on perioperative times when compared to neostigmine under general clinical practice conditions following rocuronium-induced neuromuscular blockade for laparoscopic cholecystectomy.Methods: Following institutional review board approval, data from 1,611 consecutive surgical records for laparoscopic cholecystectomy were reviewed. Patient characteristics, type of primary neuromuscular blocking reversal agent, operating room (OR) discharge times, and postanesthesia care unit (PACU) recovery times were the measures of interest. Equivalence testing was used to determine the between-group differences of the reversal agents in the two perioperative time periods of interest.Results: OR discharge times averaged 10.9 (95% CI, 10-11.8) minutes for patients administered sugammadex and 8.9 (95% CI, 8.2-9.7) minutes for patients administered neostigmine. PACU recovery times averaged 77.6 (95% CI, 74.1-81.1) minutes for sugammadex and 68.6 (95% CI, 65.9-71.3) minutes for neostigmine. Equivalence testing demonstrated no improvement in the two perioperative times with sugammadex.Conclusion: These results suggest no perioperative time savings with sugammadex when compared to neostigmine following laparoscopic cholecystectomy under general clinical practice conditions.