PT  - JOURNAL ARTICLE
AU  - Koury, Matthew
AU  - Shankar, Karthik
AU  - Klein, Walter M.
AU  - Ali, Zonera
TI  - Rare Diagnosis of Localized Breast Amyloidosis in the Setting of Lymphoplasmacytic Lymphoma
AID  - 10.31486/toj.25.0017
DP  - 2025 Sep 21
TA  - Ochsner Journal
PG  - 206--208
VI  - 25
IP  - 3
4099  - http://www.ochsnerjournal.org/content/25/3/206.short
4100  - http://www.ochsnerjournal.org/content/25/3/206.full
SO  - Ochsner J2025 Sep 21; 25
AB  - Background Localized amyloidosis of the breast is a rare diagnosis that is most often found incidentally during screening breast examinations or on imaging. This diagnosis can be associated with systemic amyloidosis or malignancy, making further investigation a necessity. Rarely, localized amyloidosis of the breast has been associated with lymphoplasmacytic lymphoma.Case Report A female in her early 70s presented with a mass noted on breast examination. After biopsy, she was diagnosed with localized amyloidosis of the breast. After bone marrow biopsy, the patient was diagnosed with lymphoplasmacytic lymphoma. No evidence of systemic amyloidosis was found. Because the patient is asymptomatic, she is not undergoing treatment, but she is monitored clinically every 6 months.Conclusion Breast amyloidosis is a rare diagnosis that should be considered when patients present with a breast mass. This case emphasizes the importance of a full diagnostic workup when breast amyloidosis is diagnosed to rule out systemic amyloidosis or an associated malignancy.