Table. Dose-Dependent Effects of Lidocaine
Plasma Level, μg/mLEffect
1-5Analgesia
>5-10Circumoral numbness
Tinnitus
Skeletal muscle twitching
Hypotension
Myocardial depression
>10-15Unconsciousness
Seizures
>15-25Apnea
Coma
>25Cardiovascular collapse