Table 4. Mean (± SEM) Age and Clinical Status of Boys and Girls With Sickle Cell Disease Independent of Vitamin A Status
VariableBoys (n = 34)Girls (n = 25)
Age, years6.62 ± 0.717.63 ± 1.01
Plasma retinol, μg/dL49.8 ± 4.9068.1 ± 5.1a
Weight, kg25.78 ± 2.6525.64 ± 3.26
Weight percentile34.05 ± 5.5939.7 ± 6.60
Height, cm121.32 ± 4.76119.86 ± 7.27
Height percentile35.76 ± 5.9541.66 ± 6.65
Pain crises0.72 ± 0.161.00 ± 0.38
Units of blood0.91 ± 0.371.41 ± 0.49
Infections0.66 ± 0.160.50 ± 0.18
Hospitalizations1.43 ± 0.331.57 ± 0.47
Hematocrit, %26.98 ± 0.9328.48 ± 0.87
Hemoglobin, g/dL8.58 ± 0.329.00 ± 0.36
White blood cells × 106/mL13.30 ± 0.8411.72 ± 1.06
C-reactive protein, mg/L8.85 ± 0.394.444 ± 1.2
Alpha-1-acid glycoprotein, g/L0.689 ± 0.060.689 ± 0.05
Retinol binding protein, mg/L21.02 ± 1.5221.63 ± 1.64
Tumor necrosis factor alpha, pg/mL59.4 ± 17.8932.55 ± 14.04
Inflammation score0.412 ± 0.120.36 ± 0.098
Health scoreb3.82 ± 0.654.35 ± 1.05
  • a P < 0.05; girls had higher mean plasma retinol concentrations than boys.

  • b Health score is the sum of the number of episodes of pain crisis, infection, hospital admission, and/or blood units received.