Neurologic symptoms | Neurologic sequelae from silent infarcts |
• Overt stroke | |
• High transcranial Doppler velocity (>200 m/s) | |
Cardiac/pulmonary symptoms | Tricuspid regurgitation velocity >2.5 m/s |
• Acute chest syndrome (≥1 episode while on a therapeutic dose of hydroxyurea) | Pulmonary hypertension |
Bone/joint symptoms | |
• Avascular necrosis/osteonecrosis (usually ≥2 joint involvement) | |
Renal/genitourinary symptoms | Renal insufficiency (need for dialysis, nephrotic syndrome) |
• Recurrent priapism requiring medical management | |
Hematologic symptoms | |
• Red cell alloimmunization from recurrent packed red blood cell transfusions | |
Hepatic symptoms | Iron overload |
| Sickle-related liver injury |
Vaso-occlusive crisis | |
• ≥2 hospitalizations for pain management despite being on therapeutic dose of hydroxyurea | |