Table 1.

Characteristics of the Studies Included in This Metaanalysis

StudyInclusion CriteriaExclusion CriteriaFollow-up, months
Di Mario et al,29 2004Chest pain <12 hours STEMI per AHA/ACC guidelines Maximum 3 diseased vesselsCardiogenic shock or need for vasopressors or balloon counterpulsation Left main disease Lesions in previously treated vessels Recent thrombolysis Single-vessel disease Diffuse calcified or severe tortuosity lesion Side branch >2.0 mm requiring a stent12
Politi et al,30 2010Chest pain <12 hours STEMI per AHA/ACC guidelinesCardiogenic shock Left main disease Previous CABG Valvular disease Unsuccessful procedures30 ± 17
Wald et al,24 2013STEMI per AHA/ACC guidelines Successfully treated artery >50% stenosis in non–infarct-related artery Treatable stenosis by PCICardiogenic shock Left main disease or equivalent Previous CABG Unable to provide consent Chronic total occlusion23
Gershlick et al,25 2015Suspected or proven STEMI Chest pain <12 hours Infarct-related artery plus at least one non–infarct-related epicardial artery >2 mm with at least one lesion >70% diameter stenosis in one plane or >50% in two planesAny exclusion criteria for primary PCI <18 years of age Clear indication for or contraindication to multivessel primary PCI according to operator judgment Previous Q wave myocardial infarction Previous CABG Cardiogenic shock Ventricular septal defect or moderate/severe mitral regurgitation Chronic kidney disease (creatinine >200 μmol/L or estimated glomerular filtration rate <30 mL/min/1.73m2) Suspected or confirmed thrombosis of a previously stented artery Only significant non–infarct-related artery lesion is a chronic total occlusion12
  • Note: AHA/ACC guidelines require at least 1 mm in two or more contiguous limb electrocardiographic leads or 2 mm in precordial leads. Cardiogenic shock is defined as systolic blood pressure <90 mmHg or heart rate >100 bpm. Left main disease is defined as >50% ostial stenosis, unsuccessful procedures, absence of residual stenosis <30%, and/or TIMI flow grade III.

  • ACC, American College of Cardiology; AHA, American Heart Association; CABG, coronary artery bypass graft; PCI, percutaneous coronary intervention; STEMI, ST elevation myocardial infarction; TIMI, Thrombolysis in Myocardial Infarction.