Table 2.

Specific Pathogens and Antibiotic Treatment of Acute Osteomyelitis in Children

Organism	Treatment	Alternatives
Methicillin-susceptible Staphylococcus aureus	Antistaphylococcal penicillins^a	Cefazolin, clindamycin
Methicillin-resistant Staphylococcus aureus	Clindamycin,^b vancomycin	Linezolid, daptomycin, trimethoprim-sulfamethoxazole
Group A Streptococcus	Penicillin G, ampicillin, amoxicillin	Clindamycin^b
Streptococcus pneumoniae	Ceftriaxone,^b clindamycin^b	Vancomycin
	Penicillin G^b
	Ampicillin, amoxicillin^b
Kingella kingae	Ampicillin or ampicillin-sulbactam
	Cephalosporin
Enteric gram-negative rods	Ceftriaxone	Ciprofloxacin
Pseudomonas aeruginosa	Ceftazidime, ticarcillin-clavulanate	Ciprofloxacin
Neisseria gonorrhoeae	Ceftriaxone	Penicillin G^b
Salmonella spp	Ceftriaxone	Ampicillin^b
Anaerobes	Penicillin, clindamycin	Metronidazole, meropenem