High-grade epithelial ovarian/tubal/peritoneal cancer Breast cancer diagnosed at ≤45 years Breast cancer and close relative with breast cancer diagnosed at ≤50 years or close relative with epithelial ovarian/tubal/peritoneal cancer at any age Breast cancer diagnosed at ≤50 years and a limited family history Breast cancer and ≥2 close relatives with breast cancer at any age Breast cancer and ≥2 close relatives with pancreatic cancer or aggressive prostate cancer (Gleason score ≥7) Two breast primaries, with the first diagnosed at <50 years Triple-negative breast cancer diagnosed at ≤60 years Breast cancer and Ashkenazi Jewish ancestry Pancreatic cancer and ≥2 close relatives with breast, ovarian/tubal/peritoneal, pancreatic, or aggressive prostate cancer (Gleason score ≥7) | First degree or several close relatives who meet one of the criteria in the left column Close relative carrying a known BRCA1 or BRCA2 mutation Close relative with male breast cancer |