Consensus Recommendations for Genetic Counseling and Testing for Cowden Syndrome26
| Major Criteria | Minor Criteria |
|---|---|
| Breast cancer Endometrial cancer Follicular thyroid cancer Multiple gastrointestinal hamartomas or ganglioneuromas Macrocephaly Mucocutaneous lesions Multiple trichilemmomas Multiple acral/palmoplantar keratosis, pits, papules Mucocutaneous neuromas Multifocal oral mucosal papillomatosis Multiple cutaneous facial papules (verrucous) | Autism spectrum disorder Colon cancer Esophageal glycogenic acanthoses Lipomas Intellectual disability Thyroid adenomas, goiter, nodules Papillary or follicular thyroid caner Renal cell carcinoma Single gastrointestinal hamartoma or ganglioneuroma Vascular anomalies |