Consensus Recommendations for Genetic Counseling and Testing for Lynch Syndrome15
| Patients With the Following |
|---|
| Endometrial or colorectal cancer with evidence of microsatellite instability or loss of a DNA mismatch repair protein (MLH1, MSH2, MSH6, PMS2) on immunohistochemistry |
| First-degree relative affected with endometrial or colorectal cancer who was either diagnosed at <60 years or who is identified to be at risk for Lynch syndrome by a systematic clinical screen that incorporates a focused personal and medical history |
| First- or second-degree relative with a known mutation in a mismatch repair gene |