Characteristics of Studies Included in the Review
| Study | N | Age, years, Sex | Dose | Grade 1 | Grade 2 | Grade 3 | Time From Administration to Reaction | Surgery Canceled | Time in SICU |
|---|---|---|---|---|---|---|---|---|---|
| Longnecker et al, 198517 | 1 | N/R | N/R | 1 | 1 min | N/R | 24 h | ||
| Leong et al, 200018 | 3 | 38, M | 4.8 mL | 1 | 30 min | Yes | 36 h | ||
| 66, F | 4.7 mL | 1 | 15 min | No | None | ||||
| 81, F | 4.8 mL | 1 | 15 min | Yes | 48 h | ||||
| Lyew et al, 20005 | 1 | 48, F | 5 mL | 1 | 5 min | No | 18 h | ||
| Cimmino et al, 200111 | 5 | 22, F | 3 mL | 1 | 10 min | N/R | Yes, time N/R | ||
| 72, M | 3 mL | 1 | 8 min | N/R | Yes, time N/R | ||||
| 50, F | 3 mL | 1 | 40 min | N/R | N/R | ||||
| 47, F | 5 mL | 1 | 30-40 min | N/R | N/R | ||||
| 47, F | 5 mL | 1 | 30-40 min | N/R | N/R | ||||
| Albo et al, 20014 | 7 | 75, F | 5 mL | 1 | 20 min | N/R | 48 h | ||
| 75, F | 5 mL | 1 | 15 min | N/R | 24 h | ||||
| 50, F | 5 mL | 1 | 15 min | N/R | 24 h | ||||
| 47, F | 5 mL | 1 | 15 min | N/R | 24 h | ||||
| 65, F | 5 mL | 1 | 30 min | N/R | 48 h | ||||
| 53, F | 5 mL | 1 | 20 min | N/R | 72 h | ||||
| 53, F | 5 mL | 1 | 30 min | N/R | 24 h | ||||
| Kuerer et al, 200119 | 1 | 75, F | 5 mL | 1 | 40 min | No | N/R | ||
| Krouse and Schwarz, 200120 | 1 | 63, F | 4 mL | 1 | N/R | No | N/R | ||
| Sadiq et al, 200121 | 2 | 52, F | 2 mL | 1 | 45 min | No | None | ||
| 57, F | 2 mL | 1 | 25 min | Yes | None | ||||
| Kuerer et al, 200122 | 1 | 52, F | 5 mL | 1 | N/R | Yes | N/R | ||
| Giménez et al, 200123 | 2 | 48, F | 4 mL | 1 | 5 min | No | N/R | ||
| 60, F | 2 mL | 1 | 5 min | No | None | ||||
| Laurie et al, 200210 | 2 | 60, F | 5 mL | 1 | 5 min | Yes | 48 h | ||
| 62, F | 5 mL | 1 | 40 min | Yes | None | ||||
| Montgomery et al, 200214 | 39 | N/R | N/R | 27 | 3 | 9 | 44 min (mean) | N/R | N/R |
| Efron et al, 200224 | 1 | 54, F | 5 mL | 1 | 10 min | No | 24 h | ||
| Stefanutto et al, 200225 | 1 | N/R | N/R | 1 | N/R | N/R | N/R | ||
| Sprung et al, 200326 | 1 | 53, F | 4 mL | 1 | 1 min | Yes | N/R | ||
| Raut et al, 200427 | 3 | N/R | 5 mL | 3 | N/R | N/R | N/R | ||
| Sandhu et al, 20056 | 1 | 45, F | 5 mL | 1 | 10 min | Yes | 48 h | ||
| Raut et al, 200515 | 4 | 73, F | 5 mL | 1 | 105 min | N/R | None | ||
| 62, F | 5 mL | 1 | 45 min | N/R | None | ||||
| 53, F | 5 mL | 1 | 75 min | N/R | None | ||||
| 58, F | 5 mL | 1 | 10 min | N/R | None | ||||
| Amr et al, 200516 | 7 | N/R | N/R | 6 | 1 | N/R | N/R | N/R | |
| Komenaka et al, 200528 | 3 | N/R | N/R | 3 | 23 min (mean) | N/R | N/R | ||
| Saft and Sarap, 200729 | 1 | 54, F | 5 mL | 1 | 20 min | Yes | N/R | ||
| Kaufman et al, 20082 | 2 | 62, F | 5 mL | 1 | 30 min | N/R | 24 h | ||
| 77, M | 1.8 mL | 1 | 1 min | N/R | 24 h | ||||
| Liang and Carson, 20087 | 1 | 48, F | 5 mL | 1 | 15 min | Yes | 36 h | ||
| O’Sullivan and Morrow, 200830 | 1 | 77, F | 8 mL | 1 | N/A | No | None | ||
| Cinar et al, 201231 | 1 | 65, F | 5 mL | 1 | 30 sec | No | 2 h | ||
| Haque and Nossaman, 20121 | 2 | 83, F | 4 mL | 1 | N/R | No | N/R | ||
| 62, F | 5 mL | 1 | Within minutes | No | N/R | ||||
| Reed et al, 201432 | 1 | 44, F | N/R | 1 | 20 min | No | N/R | ||
| Ortiz et al, 201533 | 1 | 82, F | 1 mL | 1 | 15 min | Yes | 48 h | ||
| Wang et al, 20183 | 12 | N/R | N/R | 12 | N/R | N/R | Yes, time N/R | ||
| Present Study | 2 | 46, F | 5 mL | 1 | 5 min | Yes | 18 h | ||
| 51, F | 5 mL | 1 | 25 min | No | None |
N/R, not reported; SICU, surgical intensive care unit.