Patient's Liver and Thyroid Function Test Results by Week of Gestation
| Week of Gestation | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Reference Range | 9, Admission Day 1 | 9, Admission Day 4 | 10 | 11 | 12 | 16 | 24 | 28 |
| Aspartate aminotransferase, U/L | 5-34 | 349 | 128 | 62 | 66 | 26 | 21 | 19 | 22 |
| Alanine aminotransferase, U/L | 7-56 | 676 | 378 | 172 | 91 | 35 | 19 | 16 | 20 |
| Aspartate aminotransferase/alanine aminotransferase ratio | <1 | 0.52 | 0.34 | 0.36 | 0.73 | 1.11 | 1.11 | 1.19 | 1.10 |
| Alkaline phosphatase, U/L | 40-150 | 117 | 88 | 79 | 66 | 56 | 53 | 93 | 93 |
| Gamma-glutamyl transferase, U/L | 9-36 | 208 | 135 | 106 | 108 | 61 | 28 | 27 | 27 |
| Total bilirubin, mg/dL | 0.2-1.2 | 7.1 | 1.9 | 0.8 | 1.2 | 0.6 | 0.4 | 0.5 | 0.4 |
| Direct bilirubin, mg/dL | 0.0-0.5 | 5.4 | 1.5 | 0.6 | 0.8 | 0.4 | 0.2 | 0.2 | 0.2 |
| Albumin, g/L | 35-50 | 43.2 | 27.9 | 32 | 29.2 | 33.3 | 32.4 | 32.7 | 31.5 |
| Globulin, g/L | 14-48 | 46.5 | 28.5 | 38 | 30.9 | 32.3 | 38.2 | 40.8 | 41.6 |
| Cholesterol, mg/dL | <200 | 132 | 95 | 185 | 167 | 168 | 199 | 280 | 284 |
| Prothrombin time, s | 10.5-13.5 | 14.5 | – | 11.8 | – | – | – | – | 11.6 |
| International normalized ratio | 0.91-1.17 | 1.24 | – | 0.98 | – | – | – | – | 0.97 |
| Activated partial thromboplastin time, s | 22-33 | 23.8 | – | 24.3 | – | – | – | – | 24.8 |
| Thrombin time, s | 14.4-20.8 | 17 | – | – | – | – | – | – | 15.3 |
| Total thyroxine, μg/dL | 4.87-11.72 (7.31-17.58)a | 22.5 | – | – | – | 14.2 | 14.2 | 12.8 | – |
| Free thyroxine, ng/dL | 0.7-1.48 | 4.51 | – | 1.99 | – | – | – | – | 0.94 |
| Total triiodothyronine, ng/dL | 64-152 (96-228)a | – | – | – | – | 112 | 112 | 121 | – |
| Free triiodothyronine, pg/mL | 1.88-3.18 | 5.93 | – | 4.01 | – | – | – | – | 2.26 |
| Thyroid-stimulating hormone, mU/L | 0.35-4.94 | <0.0038 | – | <0.0038 | – | 0.034 | 0.034 | 0.754 | 0.455 |
↵aThe reference ranges for total thyroxine and triiodothyronine levels for patients in the second and third trimester are 1.5-fold higher than in nonpregnant females because of thyroxine-binding globulin excess.
Note: Thyroid function tests were analyzed using the Architect i2000 immunoassay analyzer (Abbott). The analytic sensitivity is 0.4 ng/dL for free thyroxine, 1 μg/dL for total thyroxine, 1 pg/mL for free triiodothyronine, 0.25 ng/dL for total triiodothyronine, and 0.01 mU/L for thyroid-stimulating hormone.